The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia
Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T-ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inabilit...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2025.2460252 |
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| author | Majd A. Al-Hamaly Evelyn Winter Jessica S. Blackburn |
| author_facet | Majd A. Al-Hamaly Evelyn Winter Jessica S. Blackburn |
| author_sort | Majd A. Al-Hamaly |
| collection | DOAJ |
| description | Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T-ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are responsible for the long-term maintenance of the disease. Mitochondria have been recognized as a therapeutic vulnerability for cancer stem cells, including LSCs. Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in early-phase clinical trials. However, due to challenges in studying LSCs in T-ALL, our understanding of how mitochondrial function influences self-renewal remains limited. This review highlights the emerging literature on targeting mitochondria in diverse T-ALL models, emphasizing specific mitochondrial vulnerabilities linked to LSC self-renewal and their potential to significantly improve T-ALL treatment. |
| format | Article |
| id | doaj-art-3544357a0c9743b3a6603cdb3ed9c3c5 |
| institution | Kabale University |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-3544357a0c9743b3a6603cdb3ed9c3c52025-02-05T06:01:24ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762025-12-0126110.1080/15384047.2025.2460252The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemiaMajd A. Al-Hamaly0Evelyn Winter1Jessica S. Blackburn2Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USADepartment of Agriculture, Biodiversity and Forestry, Federal University of Santa Catarina, Curitibanos, BrazilMarkey Cancer Center, University of Kentucky, Lexington, KY, USAAcute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T-ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are responsible for the long-term maintenance of the disease. Mitochondria have been recognized as a therapeutic vulnerability for cancer stem cells, including LSCs. Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in early-phase clinical trials. However, due to challenges in studying LSCs in T-ALL, our understanding of how mitochondrial function influences self-renewal remains limited. This review highlights the emerging literature on targeting mitochondria in diverse T-ALL models, emphasizing specific mitochondrial vulnerabilities linked to LSC self-renewal and their potential to significantly improve T-ALL treatment.https://www.tandfonline.com/doi/10.1080/15384047.2025.2460252MitochondriaOXPHOSmetabolismself-renewalleukemia stem cellscancer stem cells |
| spellingShingle | Majd A. Al-Hamaly Evelyn Winter Jessica S. Blackburn The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia Cancer Biology & Therapy Mitochondria OXPHOS metabolism self-renewal leukemia stem cells cancer stem cells |
| title | The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia |
| title_full | The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia |
| title_fullStr | The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia |
| title_full_unstemmed | The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia |
| title_short | The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia |
| title_sort | mitochondria as an emerging target of self renewal in t cell acute lymphoblastic leukemia |
| topic | Mitochondria OXPHOS metabolism self-renewal leukemia stem cells cancer stem cells |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2025.2460252 |
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