How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults?
Aim. We hypothesized that 4 days of normal daily activity after 21 days of experimental bed rest (BR) will not reverse BR induced impaired glucose tolerance. Design. Glucose tolerance of seven male, healthy, untrained test subjects (age: 27.6 (3.3) years (mean (SD)); body mass: 78.6 (6.4) kg; height...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/803083 |
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| author | Martina Heer Natalie Baecker Stephan Wnendt Annelie Fischer Gianni Biolo Petra Frings-Meuthen |
| author_facet | Martina Heer Natalie Baecker Stephan Wnendt Annelie Fischer Gianni Biolo Petra Frings-Meuthen |
| author_sort | Martina Heer |
| collection | DOAJ |
| description | Aim. We hypothesized that 4 days of normal daily activity after 21 days of experimental bed rest (BR) will not reverse BR induced impaired glucose tolerance. Design. Glucose tolerance of seven male, healthy, untrained test subjects (age: 27.6 (3.3) years (mean (SD)); body mass: 78.6 (6.4) kg; height: 1.81 (0.04) m; VO2 max: 39.5 (5.4) ml/kg body mass/min) was studied. They stayed twice in the metabolic ward (crossover design), 21 days in bed and 7 days before and after BR each. Oral glucose tolerance tests were applied before, on day 21 of BR, and 5 and 14 days after BR. Results. On day 21 of BR, AUC120 min of glucose concentration was increased by 28.8 (5.2)% and AUC120 min of insulin by 35.9 (10.2)% (glucose: P<0.001; insulin: P=0.02). Fourteen days after BR, AUC120 min of serum insulin concentrations returned to pre-bed-rest concentrations (P=0.352) and AUC120 min of glucose was still higher (P=0.038). Insulin resistance did not change, but sensitivity index was reduced during BR (P=0.005). Conclusion. Four days of light physical workload does not compensate inactivity induced impaired glucose tolerance. An individually tailored and intensified training regime is mandatory in patients being in bed rest to get back to normal glucose metabolism in a reasonable time frame. |
| format | Article |
| id | doaj-art-3535e88cef294e7fa7d9a3c133483d52 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | The Scientific World Journal |
| spelling | doaj-art-3535e88cef294e7fa7d9a3c133483d522025-02-03T01:23:16ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/803083803083How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults?Martina Heer0Natalie Baecker1Stephan Wnendt2Annelie Fischer3Gianni Biolo4Petra Frings-Meuthen5Department of Nutrition and Food Science-Nutrition Physiology, University of Bonn, 53115 Bonn, GermanyDepartment of Nutrition and Food Science-Nutrition Physiology, University of Bonn, 53115 Bonn, GermanyMLM Medical Labs GmbH, 41066 Monchengladbach, GermanyProfil Neuss GmbH, 41460 Neuss, GermanyDivision of Internal Medicine, University of Trieste, 34127 Trieste, ItalyGerman Aerospace Center (DLR), Institute of Aerospace Medicine, 51147 Cologne, GermanyAim. We hypothesized that 4 days of normal daily activity after 21 days of experimental bed rest (BR) will not reverse BR induced impaired glucose tolerance. Design. Glucose tolerance of seven male, healthy, untrained test subjects (age: 27.6 (3.3) years (mean (SD)); body mass: 78.6 (6.4) kg; height: 1.81 (0.04) m; VO2 max: 39.5 (5.4) ml/kg body mass/min) was studied. They stayed twice in the metabolic ward (crossover design), 21 days in bed and 7 days before and after BR each. Oral glucose tolerance tests were applied before, on day 21 of BR, and 5 and 14 days after BR. Results. On day 21 of BR, AUC120 min of glucose concentration was increased by 28.8 (5.2)% and AUC120 min of insulin by 35.9 (10.2)% (glucose: P<0.001; insulin: P=0.02). Fourteen days after BR, AUC120 min of serum insulin concentrations returned to pre-bed-rest concentrations (P=0.352) and AUC120 min of glucose was still higher (P=0.038). Insulin resistance did not change, but sensitivity index was reduced during BR (P=0.005). Conclusion. Four days of light physical workload does not compensate inactivity induced impaired glucose tolerance. An individually tailored and intensified training regime is mandatory in patients being in bed rest to get back to normal glucose metabolism in a reasonable time frame.http://dx.doi.org/10.1155/2014/803083 |
| spellingShingle | Martina Heer Natalie Baecker Stephan Wnendt Annelie Fischer Gianni Biolo Petra Frings-Meuthen How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults? The Scientific World Journal |
| title | How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults? |
| title_full | How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults? |
| title_fullStr | How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults? |
| title_full_unstemmed | How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults? |
| title_short | How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults? |
| title_sort | how fast is recovery of impaired glucose tolerance after 21 day bed rest nuc study in healthy adults |
| url | http://dx.doi.org/10.1155/2014/803083 |
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