Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma?
Objective: Neoadjuvant chemotherapy (NACT) plays a major role in the treatment of patients with locally advanced breast carcinoma. Although most patients have benefited from NACT, the rate of residual tumors is still high after treatment (AT). An increase in apoptosis is expected in tru-cut biopsy (...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-03-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-59196 |
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| author | Gokce ASKAN Oguzhan OKCU Cigdem OZTURK Seda DUMAN OZTURK Bayram SEN Recep BEDIR |
| author_facet | Gokce ASKAN Oguzhan OKCU Cigdem OZTURK Seda DUMAN OZTURK Bayram SEN Recep BEDIR |
| author_sort | Gokce ASKAN |
| collection | DOAJ |
| description | Objective: Neoadjuvant chemotherapy (NACT) plays a major role in the treatment of patients with locally advanced breast carcinoma. Although most patients have benefited from NACT, the rate of residual tumors is still high after treatment (AT). An increase in apoptosis is expected in tru-cut biopsy (TCB) during treatment or AT as the mechanism of NACT is inducing apoptosis. This study aimed to investigate whether evaluating the apoptotic index (AI) from TCB can predict the response before treatment (TC-BT) and whether there is a correlation between AI and clinicopathologic parameters.
Methods: Seventy cases of breast carcinomas were included. The AI was evaluated BT and AT by quantifying the apoptosis. The receiver operating characteristic analysis was performed with overall survival (OS) data, and low and high AI cut-offs were obtained. The relationship between AI and response and clinicopathological parameters was evaluated.
Results: A significant relationship was found between low AI in TC-BT and at least partial response (p=0.025), longer OS (p=0.01) and disease-free survival (p=0.01), and progesterone receptor-positive tumors (p=0.03). Her2-negative tumors were more prone to low AI. A significant decline in AI (p=0.001) and Ki67 proliferation index (p<0.001) was observed in resections AT.
Conclusions: These data suggested that the AI is a simple and cost-effective tool that may play an important role in determining response, and a low AI in TC-BT may have some value as a predictive marker in breast carcinomas. |
| format | Article |
| id | doaj-art-352eb580ec24472f865b8510e2316bd7 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-352eb580ec24472f865b8510e2316bd72025-01-30T07:05:46ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062023-03-013811710.4274/MMJ.galenos.2022.59196MEDJ-59196Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma?Gokce ASKAN0Oguzhan OKCU1Cigdem OZTURK2Seda DUMAN OZTURK3Bayram SEN4Recep BEDIR5Recep Tayyip Erdogan University Training and Research Hospital, Department of Pathology, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Department of Pathology, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Department of Pathology, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Department of Pathology, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Department of Biochemistry, Rize, TurkeyRecep Tayyip Erdogan University Training and Research Hospital, Department of Pathology, Rize, TurkeyObjective: Neoadjuvant chemotherapy (NACT) plays a major role in the treatment of patients with locally advanced breast carcinoma. Although most patients have benefited from NACT, the rate of residual tumors is still high after treatment (AT). An increase in apoptosis is expected in tru-cut biopsy (TCB) during treatment or AT as the mechanism of NACT is inducing apoptosis. This study aimed to investigate whether evaluating the apoptotic index (AI) from TCB can predict the response before treatment (TC-BT) and whether there is a correlation between AI and clinicopathologic parameters. Methods: Seventy cases of breast carcinomas were included. The AI was evaluated BT and AT by quantifying the apoptosis. The receiver operating characteristic analysis was performed with overall survival (OS) data, and low and high AI cut-offs were obtained. The relationship between AI and response and clinicopathological parameters was evaluated. Results: A significant relationship was found between low AI in TC-BT and at least partial response (p=0.025), longer OS (p=0.01) and disease-free survival (p=0.01), and progesterone receptor-positive tumors (p=0.03). Her2-negative tumors were more prone to low AI. A significant decline in AI (p=0.001) and Ki67 proliferation index (p<0.001) was observed in resections AT. Conclusions: These data suggested that the AI is a simple and cost-effective tool that may play an important role in determining response, and a low AI in TC-BT may have some value as a predictive marker in breast carcinomas.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-59196apoptosisapoptotic indexbreast cancerneoadjuvant chemotherapyresponse |
| spellingShingle | Gokce ASKAN Oguzhan OKCU Cigdem OZTURK Seda DUMAN OZTURK Bayram SEN Recep BEDIR Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma? Medeniyet Medical Journal apoptosis apoptotic index breast cancer neoadjuvant chemotherapy response |
| title | Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma? |
| title_full | Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma? |
| title_fullStr | Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma? |
| title_full_unstemmed | Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma? |
| title_short | Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma? |
| title_sort | does apoptotic index predict the response to neoadjuvant chemotherapy in patients with breast carcinoma |
| topic | apoptosis apoptotic index breast cancer neoadjuvant chemotherapy response |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-59196 |
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