Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator
We propose chlorpromazine (CHP) as a new mediator for the rapid, sensitive, and highly selective voltammetric determination of homocysteine (Hcy) using multiwall carbon nanotube paste electrode (MWCNTPE). The experimental results showed that the carbon nanotube paste electrode has a highly electroca...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/902184 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556806238371840 |
|---|---|
| author | Fathali Gholami-Orimi Farshad Taleshi Pourya Biparva Hassan Karimi-Maleh Hadi Beitollahi Hamid R. Ebrahimi Mohamad Shamshiri Hasan Bagheri Masoud Fouladgar Ali Taherkhani |
| author_facet | Fathali Gholami-Orimi Farshad Taleshi Pourya Biparva Hassan Karimi-Maleh Hadi Beitollahi Hamid R. Ebrahimi Mohamad Shamshiri Hasan Bagheri Masoud Fouladgar Ali Taherkhani |
| author_sort | Fathali Gholami-Orimi |
| collection | DOAJ |
| description | We propose chlorpromazine (CHP) as a new mediator for the rapid, sensitive, and highly selective voltammetric determination of homocysteine (Hcy) using multiwall carbon nanotube paste electrode (MWCNTPE). The experimental results showed that the carbon nanotube paste electrode has a highly electrocatalytic activity for the oxidation of Hcy in the presence of CHP as a mediator. Cyclic voltammetry, double potential step chronoamperometry, and square wave voltammetry (SWV) are used to investigate the suitability of CHP at the surface of MWCNTPE as a mediator for the electrocatalytic oxidation of Hcy in aqueous solutions. The kinetic parameters of the system, including electron transfer coefficient, and catalytic rate constant were also determined using the electrochemical approaches. In addition, SWV was used for quantitative analysis. SWV showed wide linear dynamic range (0.1–210.0 μM Hcy) with a detection limit of 0.08 μM Hcy. Finally, this method was also examined as a selective, simple, and precise electrochemical sensor for the determination of Hcy in real samples. |
| format | Article |
| id | doaj-art-352202733f204193a258be29524cfaa1 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-352202733f204193a258be29524cfaa12025-02-03T05:44:16ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732012-01-01201210.1155/2012/902184902184Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a MediatorFathali Gholami-Orimi0Farshad Taleshi1Pourya Biparva2Hassan Karimi-Maleh3Hadi Beitollahi4Hamid R. Ebrahimi5Mohamad Shamshiri6Hasan Bagheri7Masoud Fouladgar8Ali Taherkhani9Department of Chemisty, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IranDepartment of Applied Science, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IranDepartment of Nanotechnology, Langaroud Branch, Islamic Azad University, Langaroud, IranDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Mazandaran, IranEnvironment Department, Research Institute of Environmental Sciences, International Center for Science, High Technology & Environmental Sciences, Kerman, IranDepartment of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan, IranDepartment of Medical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Chemisty, Takestan Branch, Islamic Azad University, Takestan, IranDepartment of Biochemistry, Falavarjan Branch, Islamic Azad University, Falavarjan, IranDepartment of Physics, Takestan Branch, Islamic Azad University, Takestan, IranWe propose chlorpromazine (CHP) as a new mediator for the rapid, sensitive, and highly selective voltammetric determination of homocysteine (Hcy) using multiwall carbon nanotube paste electrode (MWCNTPE). The experimental results showed that the carbon nanotube paste electrode has a highly electrocatalytic activity for the oxidation of Hcy in the presence of CHP as a mediator. Cyclic voltammetry, double potential step chronoamperometry, and square wave voltammetry (SWV) are used to investigate the suitability of CHP at the surface of MWCNTPE as a mediator for the electrocatalytic oxidation of Hcy in aqueous solutions. The kinetic parameters of the system, including electron transfer coefficient, and catalytic rate constant were also determined using the electrochemical approaches. In addition, SWV was used for quantitative analysis. SWV showed wide linear dynamic range (0.1–210.0 μM Hcy) with a detection limit of 0.08 μM Hcy. Finally, this method was also examined as a selective, simple, and precise electrochemical sensor for the determination of Hcy in real samples.http://dx.doi.org/10.1155/2012/902184 |
| spellingShingle | Fathali Gholami-Orimi Farshad Taleshi Pourya Biparva Hassan Karimi-Maleh Hadi Beitollahi Hamid R. Ebrahimi Mohamad Shamshiri Hasan Bagheri Masoud Fouladgar Ali Taherkhani Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator Journal of Analytical Methods in Chemistry |
| title | Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator |
| title_full | Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator |
| title_fullStr | Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator |
| title_full_unstemmed | Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator |
| title_short | Voltammetric Determination of Homocysteine Using Multiwall Carbon Nanotube Paste Electrode in the Presence of Chlorpromazine as a Mediator |
| title_sort | voltammetric determination of homocysteine using multiwall carbon nanotube paste electrode in the presence of chlorpromazine as a mediator |
| url | http://dx.doi.org/10.1155/2012/902184 |
| work_keys_str_mv | AT fathaligholamiorimi voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT farshadtaleshi voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT pouryabiparva voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT hassankarimimaleh voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT hadibeitollahi voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT hamidrebrahimi voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT mohamadshamshiri voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT hasanbagheri voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT masoudfouladgar voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator AT alitaherkhani voltammetricdeterminationofhomocysteineusingmultiwallcarbonnanotubepasteelectrodeinthepresenceofchlorpromazineasamediator |