Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients
Objective. The objective of the study was to assess the relationship between selected clinical and biochemical parameters of end stage renal disease (ESRD) patients and arterial calcification. Materials and Methods. The study comprised 59 stage 5 chronic kidney disease patients (36 hemodialyzed and...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/969038 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558643829014528 |
|---|---|
| author | Katarzyna Janda Marcin Krzanowski Mariusz Gajda Paulina Dumnicka Danuta Fedak Grzegorz J. Lis Piotr Jaśkowski Jan A. Litwin Władysław Sułowicz |
| author_facet | Katarzyna Janda Marcin Krzanowski Mariusz Gajda Paulina Dumnicka Danuta Fedak Grzegorz J. Lis Piotr Jaśkowski Jan A. Litwin Władysław Sułowicz |
| author_sort | Katarzyna Janda |
| collection | DOAJ |
| description | Objective. The objective of the study was to assess the relationship between selected clinical and biochemical parameters of end stage renal disease (ESRD) patients and arterial calcification. Materials and Methods. The study comprised 59 stage 5 chronic kidney disease patients (36 hemodialyzed and 23 predialysis). The examined parameters included common carotid artery intima-media thickness (CCA-IMT), BMI, incidence of diabetes and impaired fasting glucose (IFG), dyslipidemia, hypertension, and 3-year mortality. Plasma levels asymmetric dimethylarginine (ADMA), osteopontin (OPN), osteoprotegerin (OPG), and osteocalcin (OC) were also measured. Fragments of radial artery obtained during creation of hemodialysis access were stained for calcifications using von Kossa method and alizarin red. Results. Calcification of radial artery was significantly associated with higher prevalence of IFG and diabetes (P=0.0004) and older age (P=0.003), as well as higher OPG (P=0.014) and ADMA concentrations (P=0.022). Fasting glucose >5.6 mmol/l (IFG and diabetes) significantly predicted vascular calcification in multiple logistic regression. The calcification was also associated with higher CCA-IMT (P=0.006) and mortality (P=0.004; OR for death 5.39 [1.20–24.1] after adjustment for dialysis status and age). Conclusion. Combination of renal insufficiency and hyperglycemic conditions exerts a synergistic effect on vascular calcification and increases the risk of death. |
| format | Article |
| id | doaj-art-35193b3f373746b490cc20c03aadd249 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-35193b3f373746b490cc20c03aadd2492025-02-03T01:31:56ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/969038969038Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease PatientsKatarzyna Janda0Marcin Krzanowski1Mariusz Gajda2Paulina Dumnicka3Danuta Fedak4Grzegorz J. Lis5Piotr Jaśkowski6Jan A. Litwin7Władysław Sułowicz8Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Krakow, PolandChair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Krakow, PolandChair and Department of Histology, Jagiellonian University Medical College, 31-501 Krakow, PolandDepartment of Medical Diagnostics, Jagiellonian University Medical College, 31-501 Krakow, PolandChair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Krakow, PolandChair and Department of Histology, Jagiellonian University Medical College, 31-501 Krakow, PolandChair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Krakow, PolandChair and Department of Histology, Jagiellonian University Medical College, 31-501 Krakow, PolandChair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Krakow, PolandObjective. The objective of the study was to assess the relationship between selected clinical and biochemical parameters of end stage renal disease (ESRD) patients and arterial calcification. Materials and Methods. The study comprised 59 stage 5 chronic kidney disease patients (36 hemodialyzed and 23 predialysis). The examined parameters included common carotid artery intima-media thickness (CCA-IMT), BMI, incidence of diabetes and impaired fasting glucose (IFG), dyslipidemia, hypertension, and 3-year mortality. Plasma levels asymmetric dimethylarginine (ADMA), osteopontin (OPN), osteoprotegerin (OPG), and osteocalcin (OC) were also measured. Fragments of radial artery obtained during creation of hemodialysis access were stained for calcifications using von Kossa method and alizarin red. Results. Calcification of radial artery was significantly associated with higher prevalence of IFG and diabetes (P=0.0004) and older age (P=0.003), as well as higher OPG (P=0.014) and ADMA concentrations (P=0.022). Fasting glucose >5.6 mmol/l (IFG and diabetes) significantly predicted vascular calcification in multiple logistic regression. The calcification was also associated with higher CCA-IMT (P=0.006) and mortality (P=0.004; OR for death 5.39 [1.20–24.1] after adjustment for dialysis status and age). Conclusion. Combination of renal insufficiency and hyperglycemic conditions exerts a synergistic effect on vascular calcification and increases the risk of death.http://dx.doi.org/10.1155/2013/969038 |
| spellingShingle | Katarzyna Janda Marcin Krzanowski Mariusz Gajda Paulina Dumnicka Danuta Fedak Grzegorz J. Lis Piotr Jaśkowski Jan A. Litwin Władysław Sułowicz Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients International Journal of Endocrinology |
| title | Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients |
| title_full | Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients |
| title_fullStr | Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients |
| title_full_unstemmed | Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients |
| title_short | Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients |
| title_sort | impaired fasting glucose and diabetes as predictors for radial artery calcification in end stage renal disease patients |
| url | http://dx.doi.org/10.1155/2013/969038 |
| work_keys_str_mv | AT katarzynajanda impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients AT marcinkrzanowski impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients AT mariuszgajda impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients AT paulinadumnicka impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients AT danutafedak impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients AT grzegorzjlis impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients AT piotrjaskowski impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients AT janalitwin impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients AT władysławsułowicz impairedfastingglucoseanddiabetesaspredictorsforradialarterycalcificationinendstagerenaldiseasepatients |