An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis
In children, acute pancreatitis has been reported in IgA vasculitis, Kawasaki disease, systemic lupus erythematosus-associated vasculitis, and juvenile dermatomyositis-associated vasculitis. However, its frequency in these vasculitides has been shown to be low. In other childhood-onset vasculitides,...
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Wiley
2019-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2019/9053747 |
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| author | Haruna Yagi Seishiro Takahashi Tetsuo Kibe Kenji Shirai Isao Kosugi Hideya Kawasaki Shiori Meguro Toshihide Iwashita Hiroshi Ogawa |
| author_facet | Haruna Yagi Seishiro Takahashi Tetsuo Kibe Kenji Shirai Isao Kosugi Hideya Kawasaki Shiori Meguro Toshihide Iwashita Hiroshi Ogawa |
| author_sort | Haruna Yagi |
| collection | DOAJ |
| description | In children, acute pancreatitis has been reported in IgA vasculitis, Kawasaki disease, systemic lupus erythematosus-associated vasculitis, and juvenile dermatomyositis-associated vasculitis. However, its frequency in these vasculitides has been shown to be low. In other childhood-onset vasculitides, acute pancreatitis is seldom reported. The patient was a 5-year-old Japanese boy who suddenly presented with gastrointestinal (GI) bleeding. Therapy with antiulcer drugs successfully stopped bleeding, but subsequently, high fever, leukocytosis, and hypoxia appeared. He died 12 days after he presented with GI bleeding. An autopsy unexpectedly revealed that necrotizing vasculitis with marked eosinophilic and histiocytic infiltration of the pancreas led to acute pancreatitis, and gastric ulcer with eosinophilic infiltration was shown to be the origin of GI bleeding. In addition, eosinophilic infiltration was found in the small intestine, lungs, and bone marrow. Necrotizing vasculitis with eosinophilic and histiocytic infiltration of the pancreas, eosinophilic infiltration of the airway wall, and eosinophilic gastroenteritis with gastric ulcer were histologically confirmed, suggesting that the present case may be an early stage of eosinophilic granulomatosis with polyangiitis- (EGPA-) like vasculitis. To our knowledge, this might be the first reported case of EGPA-like vasculitis presenting with acute pancreatitis in a child. |
| format | Article |
| id | doaj-art-350aab352602403cbf88154b14e06bbd |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-350aab352602403cbf88154b14e06bbd2025-02-03T01:23:07ZengWileyCase Reports in Rheumatology2090-68892090-68972019-01-01201910.1155/2019/90537479053747An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing VasculitisHaruna Yagi0Seishiro Takahashi1Tetsuo Kibe2Kenji Shirai3Isao Kosugi4Hideya Kawasaki5Shiori Meguro6Toshihide Iwashita7Hiroshi Ogawa8Department of Diagnostic Pathology, Seirei Mikatahara Hospital, 3453 Mikataharacho, Hamamatsu 433-8558, JapanDepartment of Diagnostic Pathology, Seirei Mikatahara Hospital, 3453 Mikataharacho, Hamamatsu 433-8558, JapanDepartment of Pediatrics, Seirei Mikatahara Hospital, 3453 Mikataharacho, Hamamatsu 433-8558, JapanDepartment of Pediatrics, Seirei Mikatahara Hospital, 3453 Mikataharacho, Hamamatsu 433-8558, JapanDepartment of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, JapanDepartment of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, JapanDepartment of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, JapanDepartment of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, JapanDepartment of Diagnostic Pathology, Seirei Mikatahara Hospital, 3453 Mikataharacho, Hamamatsu 433-8558, JapanIn children, acute pancreatitis has been reported in IgA vasculitis, Kawasaki disease, systemic lupus erythematosus-associated vasculitis, and juvenile dermatomyositis-associated vasculitis. However, its frequency in these vasculitides has been shown to be low. In other childhood-onset vasculitides, acute pancreatitis is seldom reported. The patient was a 5-year-old Japanese boy who suddenly presented with gastrointestinal (GI) bleeding. Therapy with antiulcer drugs successfully stopped bleeding, but subsequently, high fever, leukocytosis, and hypoxia appeared. He died 12 days after he presented with GI bleeding. An autopsy unexpectedly revealed that necrotizing vasculitis with marked eosinophilic and histiocytic infiltration of the pancreas led to acute pancreatitis, and gastric ulcer with eosinophilic infiltration was shown to be the origin of GI bleeding. In addition, eosinophilic infiltration was found in the small intestine, lungs, and bone marrow. Necrotizing vasculitis with eosinophilic and histiocytic infiltration of the pancreas, eosinophilic infiltration of the airway wall, and eosinophilic gastroenteritis with gastric ulcer were histologically confirmed, suggesting that the present case may be an early stage of eosinophilic granulomatosis with polyangiitis- (EGPA-) like vasculitis. To our knowledge, this might be the first reported case of EGPA-like vasculitis presenting with acute pancreatitis in a child.http://dx.doi.org/10.1155/2019/9053747 |
| spellingShingle | Haruna Yagi Seishiro Takahashi Tetsuo Kibe Kenji Shirai Isao Kosugi Hideya Kawasaki Shiori Meguro Toshihide Iwashita Hiroshi Ogawa An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis Case Reports in Rheumatology |
| title | An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis |
| title_full | An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis |
| title_fullStr | An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis |
| title_full_unstemmed | An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis |
| title_short | An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis |
| title_sort | autopsy case of a 5 year old child with acute pancreatitis caused by eosinophilic granulomatosis with polyangiitis like necrotizing vasculitis |
| url | http://dx.doi.org/10.1155/2019/9053747 |
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