Decoding mitochondrial DNA damage and repair associated with H. pylori infection
Mitochondrial genomic stability is critical to prevent various human inflammatory diseases. Bacterial infection significantly increases oxidative stress, driving mitochondrial genomic instability and initiating inflammatory human disease. Oxidative DNA base damage is predominantly repaired by base e...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1529441/full |
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| author | Aashirwad Shahi Dawit Kidane |
| author_facet | Aashirwad Shahi Dawit Kidane |
| author_sort | Aashirwad Shahi |
| collection | DOAJ |
| description | Mitochondrial genomic stability is critical to prevent various human inflammatory diseases. Bacterial infection significantly increases oxidative stress, driving mitochondrial genomic instability and initiating inflammatory human disease. Oxidative DNA base damage is predominantly repaired by base excision repair (BER) in the nucleus (nBER) as well as in the mitochondria (mtBER). In this review, we summarize the molecular mechanisms of spontaneous and H. pylori infection-associated oxidative mtDNA damage, mtDNA replication stress, and its impact on innate immune signaling. Additionally, we discuss how mutations located on mitochondria targeting sequence (MTS) of BER genes may contribute to mtDNA genome instability and innate immune signaling activation. Overall, the review summarizes evidence to understand the dynamics of mitochondria genome and the impact of mtBER in innate immune response during H. pylori-associated pathological outcomes. |
| format | Article |
| id | doaj-art-35075a11ee654719afd92b3d0d6d2598 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-35075a11ee654719afd92b3d0d6d25982025-01-21T05:43:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.15294411529441Decoding mitochondrial DNA damage and repair associated with H. pylori infectionAashirwad ShahiDawit KidaneMitochondrial genomic stability is critical to prevent various human inflammatory diseases. Bacterial infection significantly increases oxidative stress, driving mitochondrial genomic instability and initiating inflammatory human disease. Oxidative DNA base damage is predominantly repaired by base excision repair (BER) in the nucleus (nBER) as well as in the mitochondria (mtBER). In this review, we summarize the molecular mechanisms of spontaneous and H. pylori infection-associated oxidative mtDNA damage, mtDNA replication stress, and its impact on innate immune signaling. Additionally, we discuss how mutations located on mitochondria targeting sequence (MTS) of BER genes may contribute to mtDNA genome instability and innate immune signaling activation. Overall, the review summarizes evidence to understand the dynamics of mitochondria genome and the impact of mtBER in innate immune response during H. pylori-associated pathological outcomes.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1529441/fullmitochondrial DNA damage and repairH. pylorigenomic instabilitycytosolic DNAinnate immune signalingType I interferon response |
| spellingShingle | Aashirwad Shahi Dawit Kidane Decoding mitochondrial DNA damage and repair associated with H. pylori infection Frontiers in Cellular and Infection Microbiology mitochondrial DNA damage and repair H. pylori genomic instability cytosolic DNA innate immune signaling Type I interferon response |
| title | Decoding mitochondrial DNA damage and repair associated with H. pylori infection |
| title_full | Decoding mitochondrial DNA damage and repair associated with H. pylori infection |
| title_fullStr | Decoding mitochondrial DNA damage and repair associated with H. pylori infection |
| title_full_unstemmed | Decoding mitochondrial DNA damage and repair associated with H. pylori infection |
| title_short | Decoding mitochondrial DNA damage and repair associated with H. pylori infection |
| title_sort | decoding mitochondrial dna damage and repair associated with h pylori infection |
| topic | mitochondrial DNA damage and repair H. pylori genomic instability cytosolic DNA innate immune signaling Type I interferon response |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1529441/full |
| work_keys_str_mv | AT aashirwadshahi decodingmitochondrialdnadamageandrepairassociatedwithhpyloriinfection AT dawitkidane decodingmitochondrialdnadamageandrepairassociatedwithhpyloriinfection |