Obesity Hypertension: The Regulatory Role of Leptin
Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake and elevation in temperature and energy expendit...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/270624 |
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| author | Shilpa Kshatriya Kan Liu Ali Salah Tamas Szombathy Ronald H. Freeman Garry P. Reams Robert M. Spear Daniel Villarreal |
| author_facet | Shilpa Kshatriya Kan Liu Ali Salah Tamas Szombathy Ronald H. Freeman Garry P. Reams Robert M. Spear Daniel Villarreal |
| author_sort | Shilpa Kshatriya |
| collection | DOAJ |
| description | Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake and elevation in temperature and energy expenditure. In addition, increasing evidence suggests that leptin, through both direct and indirect mechanisms, may play an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and possibly also for direct renal, vascular, and cardiac damage. |
| format | Article |
| id | doaj-art-34ff9e78f35f45989331417f18e35038 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-34ff9e78f35f45989331417f18e350382025-02-03T05:59:21ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/270624270624Obesity Hypertension: The Regulatory Role of LeptinShilpa Kshatriya0Kan Liu1Ali Salah2Tamas Szombathy3Ronald H. Freeman4Garry P. Reams5Robert M. Spear6Daniel Villarreal7Department of Internal Medicine, SUNY Upstate Medical University, Veterans Affairs Medical Center, Syracuse, NY 13210, USADepartment of Internal Medicine, SUNY Upstate Medical University, Veterans Affairs Medical Center, Syracuse, NY 13210, USADepartment of Internal Medicine, SUNY Upstate Medical University, Veterans Affairs Medical Center, Syracuse, NY 13210, USADepartment of Internal Medicine, SUNY Upstate Medical University, Veterans Affairs Medical Center, Syracuse, NY 13210, USADepartment of Internal Medicine and Physiology, University of Missouri-Columbia, Columbia, MO 65212, USADepartment of Internal Medicine and Physiology, University of Missouri-Columbia, Columbia, MO 65212, USADepartment of Internal Medicine, SUNY Upstate Medical University, Veterans Affairs Medical Center, Syracuse, NY 13210, USADepartment of Internal Medicine, SUNY Upstate Medical University, Veterans Affairs Medical Center, Syracuse, NY 13210, USALeptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake and elevation in temperature and energy expenditure. In addition, increasing evidence suggests that leptin, through both direct and indirect mechanisms, may play an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and possibly also for direct renal, vascular, and cardiac damage.http://dx.doi.org/10.4061/2011/270624 |
| spellingShingle | Shilpa Kshatriya Kan Liu Ali Salah Tamas Szombathy Ronald H. Freeman Garry P. Reams Robert M. Spear Daniel Villarreal Obesity Hypertension: The Regulatory Role of Leptin International Journal of Hypertension |
| title | Obesity Hypertension: The Regulatory Role of Leptin |
| title_full | Obesity Hypertension: The Regulatory Role of Leptin |
| title_fullStr | Obesity Hypertension: The Regulatory Role of Leptin |
| title_full_unstemmed | Obesity Hypertension: The Regulatory Role of Leptin |
| title_short | Obesity Hypertension: The Regulatory Role of Leptin |
| title_sort | obesity hypertension the regulatory role of leptin |
| url | http://dx.doi.org/10.4061/2011/270624 |
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