Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome

Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome

Abstract Increasing shreds of evidence suggest that neurogenic-to-gliogenic shift may be critical to the abnormal neurodevelopment observed in individuals with Down syndrome (DS). REST, the Repressor Element-1 Silencing Transcription factor, regulates the differentiation and development of neural ce...

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Bibliographic Details
Main Authors: Tan Huang, Sharida Fakurazi, Pike-See Cheah, King-Hwa Ling
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
REST
NPC
Down syndrome
Neurogenesis
Gliogenesis
Online Access:https://doi.org/10.1038/s41598-025-87314-y
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