miR-210 locus deletion disrupts cellular homeostasis: an integrated genetic study

miR-210 locus deletion disrupts cellular homeostasis: an integrated genetic study

Abstract MiR-210 is widely recognized as the quintessential hypoxia-responsive miRNA and is thought to fine-tune various facets of cellular homeostasis. We hereby present an integrative appraisal of the phenotypic and molecular repercussions of disrupting the corresponding locus in human and mouse c...

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Main Authors: Mihai Bogdan Preda, Evelyn Gabriela Nastase-Rusu, Carmen Alexandra Neculachi, Xiaoling Zhong, Christine Voellenkle, Nathalie M. Mazure, Ovidiu Balacescu, Cristina Ivan, Xiao-Wei Zheng, Mihaela Gherghiceanu, Kevin Lebrigand, Maya Simionescu, Fabio Martelli, Bernard Mari, Sergiu-Bogdan Catrina, Alexandrina Burlacu, Mircea Ivan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Gene editing technologies
Genomic neighborhood
Hypoxia
miR-210
Targets
Online Access:https://doi.org/10.1038/s41598-025-07572-8
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