Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia
Background: Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for...
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2025-01-01
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| author | Anastasia A. Zabolotneva Katerina E. Popruga Valentin V. Makarov Sergei M. Yudin Andrei M. Gaponov Sergei A. Roumiantsev Aleksandr V. Shestopalov |
| author_facet | Anastasia A. Zabolotneva Katerina E. Popruga Valentin V. Makarov Sergei M. Yudin Andrei M. Gaponov Sergei A. Roumiantsev Aleksandr V. Shestopalov |
| author_sort | Anastasia A. Zabolotneva |
| collection | DOAJ |
| description | Background: Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions. Methods: In this study, the researchers conducted a broad parallel investigation of olivetol’s effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia. Results: According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in <i>ldlr</i>(−/−) mice, decreased serum glucose levels in <i>db</i>/<i>db</i> mice, improved lipid metabolism in <i>ldlr</i>(−/−) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as <i>Akkermansia muciniphila</i> and <i>Bacteroides acidifaciens</i> and depleting the representation of pathobionts such as <i>Prevotella</i>, although olivetol supplementation did not influence the diversity or richness of the communities. Conclusions: These results suggest that olivetol is a promising therapeutic agent for preventing, treating, or alleviating the metabolic complications of obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia; however, more investigations are required in order to attain a full understanding of its physiological effects. |
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| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-34f399c01e0a493d9e24844e6a7a1fca2025-01-24T13:24:18ZengMDPI AGBiomedicines2227-90592025-01-0113118310.3390/biomedicines13010183Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and HypercholesterolemiaAnastasia A. Zabolotneva0Katerina E. Popruga1Valentin V. Makarov2Sergei M. Yudin3Andrei M. Gaponov4Sergei A. Roumiantsev5Aleksandr V. Shestopalov6Department of Biochemistry and Molecular Biology, Faculty of Medicine, FSAEI HE N. I. Pirogov Russian National Research Medical University of MOH of Russia, 1 Ostrovitianov Str., 117997 Moscow, RussiaCenter for Strategic Planning and Management of Medical and Biological Health Risks of FMBA of Russia; Pogodinskya Str., h.10, b.1, 119121 Moscow, RussiaCenter for Strategic Planning and Management of Medical and Biological Health Risks of FMBA of Russia; Pogodinskya Str., h.10, b.1, 119121 Moscow, RussiaCenter for Strategic Planning and Management of Medical and Biological Health Risks of FMBA of Russia; Pogodinskya Str., h.10, b.1, 119121 Moscow, RussiaV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 141534 Moscow, RussiaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, FSAEI HE N. I. Pirogov Russian National Research Medical University of MOH of Russia, 1 Ostrovitianov Str., 117997 Moscow, RussiaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, FSAEI HE N. I. Pirogov Russian National Research Medical University of MOH of Russia, 1 Ostrovitianov Str., 117997 Moscow, RussiaBackground: Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions. Methods: In this study, the researchers conducted a broad parallel investigation of olivetol’s effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia. Results: According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in <i>ldlr</i>(−/−) mice, decreased serum glucose levels in <i>db</i>/<i>db</i> mice, improved lipid metabolism in <i>ldlr</i>(−/−) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as <i>Akkermansia muciniphila</i> and <i>Bacteroides acidifaciens</i> and depleting the representation of pathobionts such as <i>Prevotella</i>, although olivetol supplementation did not influence the diversity or richness of the communities. Conclusions: These results suggest that olivetol is a promising therapeutic agent for preventing, treating, or alleviating the metabolic complications of obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia; however, more investigations are required in order to attain a full understanding of its physiological effects.https://www.mdpi.com/2227-9059/13/1/183alkylresorcinolsolivetolobesitymetabolic disordersmouse gut microbiota<i>db</i>/<i>db</i> mice |
| spellingShingle | Anastasia A. Zabolotneva Katerina E. Popruga Valentin V. Makarov Sergei M. Yudin Andrei M. Gaponov Sergei A. Roumiantsev Aleksandr V. Shestopalov Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia Biomedicines alkylresorcinols olivetol obesity metabolic disorders mouse gut microbiota <i>db</i>/<i>db</i> mice |
| title | Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia |
| title_full | Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia |
| title_fullStr | Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia |
| title_full_unstemmed | Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia |
| title_short | Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia |
| title_sort | olivetol s effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity diabetes mellitus type 1 and 2 and hypercholesterolemia |
| topic | alkylresorcinols olivetol obesity metabolic disorders mouse gut microbiota <i>db</i>/<i>db</i> mice |
| url | https://www.mdpi.com/2227-9059/13/1/183 |
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