HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS
Purpose. Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and HLA-C alleles have been associated with AIDS disease outcome, we typed HLA-C locus in patients with AIDS exhibiting or not CR. Methods. Three groups of individuals were studied: (i) 49 pa...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/3830104 |
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| author | Tânia Gisela Biberg-Salum Maria de Lourdes Veronese Rodrigues Ana Paula Morais Fernandes Neifi Hassan Salum Deghaide Jayter Silva de Paula Erick C. Castelli Celso Teixeira Mendes-Junior Eduardo Antonio Donadi |
| author_facet | Tânia Gisela Biberg-Salum Maria de Lourdes Veronese Rodrigues Ana Paula Morais Fernandes Neifi Hassan Salum Deghaide Jayter Silva de Paula Erick C. Castelli Celso Teixeira Mendes-Junior Eduardo Antonio Donadi |
| author_sort | Tânia Gisela Biberg-Salum |
| collection | DOAJ |
| description | Purpose. Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and HLA-C alleles have been associated with AIDS disease outcome, we typed HLA-C locus in patients with AIDS exhibiting or not CR. Methods. Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). HLA-C typing was performed using commercial kits. Results. The HLA-C∗07 allele group was underrepresented in AIDS patients with CR (P=0.005) when compared to controls or when compared to AIDS patients without CR (P=0.006). The HLA-C∗05 allele group was overrepresented in Group II in comparison to Group III (P=0.017). The frequency of the HLA-C∗16 allele group was increased in Group III in comparison to Group II (P=0.004). Conclusion. The HLA-C∗07 allele group conferred protection against the development of CR in Brazilian AIDS patients, whereas the HLA-C∗05 and HLA-C∗16 allele groups were associated with AIDS susceptibility or protection, respectively. |
| format | Article |
| id | doaj-art-34f051ec122f46c29ec8f54862cc1cfb |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-34f051ec122f46c29ec8f54862cc1cfb2025-02-03T06:42:29ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/38301043830104HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDSTânia Gisela Biberg-Salum0Maria de Lourdes Veronese Rodrigues1Ana Paula Morais Fernandes2Neifi Hassan Salum Deghaide3Jayter Silva de Paula4Erick C. Castelli5Celso Teixeira Mendes-Junior6Eduardo Antonio Donadi7Ribeirao Preto Medical School, University of São Paulo, University for Development of Pantanal Region (UNIDERP), São Paulo, SP, BrazilDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of São Paulo, São Paulo, SP, BrazilDepartment of General and Specialized Nursing, Nursing School of Ribeirao Preto, University of São Paulo, São Paulo, SP, BrazilMolecular Immunology Laboratory and HLA Hemocentro, Ribeirão Preto Medical School University Hospital, Ribeirão Preto, BrazilDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of São Paulo, São Paulo, SP, BrazilSchool of Medicine, Department of Pathology and Molecular Genetics and Bioinformatics Laboratory, São Paulo State University, Botucatu, SP, BrazilDepartamento de Química, Laboratório de Pesquisas Forenses e Genômicas, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901 Ribeirão Preto, SP, BrazilMolecular Immunology Laboratory and HLA Hemocentro, Ribeirão Preto Medical School University Hospital, Ribeirão Preto, BrazilPurpose. Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and HLA-C alleles have been associated with AIDS disease outcome, we typed HLA-C locus in patients with AIDS exhibiting or not CR. Methods. Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). HLA-C typing was performed using commercial kits. Results. The HLA-C∗07 allele group was underrepresented in AIDS patients with CR (P=0.005) when compared to controls or when compared to AIDS patients without CR (P=0.006). The HLA-C∗05 allele group was overrepresented in Group II in comparison to Group III (P=0.017). The frequency of the HLA-C∗16 allele group was increased in Group III in comparison to Group II (P=0.004). Conclusion. The HLA-C∗07 allele group conferred protection against the development of CR in Brazilian AIDS patients, whereas the HLA-C∗05 and HLA-C∗16 allele groups were associated with AIDS susceptibility or protection, respectively.http://dx.doi.org/10.1155/2018/3830104 |
| spellingShingle | Tânia Gisela Biberg-Salum Maria de Lourdes Veronese Rodrigues Ana Paula Morais Fernandes Neifi Hassan Salum Deghaide Jayter Silva de Paula Erick C. Castelli Celso Teixeira Mendes-Junior Eduardo Antonio Donadi HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS Journal of Ophthalmology |
| title | HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
| title_full | HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
| title_fullStr | HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
| title_full_unstemmed | HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
| title_short | HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
| title_sort | hla c alleles and cytomegalovirus retinitis in brazilian patients with aids |
| url | http://dx.doi.org/10.1155/2018/3830104 |
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