Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology
Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine and amphetamine class of psychoactive drugs, which are widely abused for their stimulant, euphoric, empathogenic, and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotoni...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/103969 |
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| author | Shaobin Yu Ling Zhu Qiang Shen Xue Bai Xuhui Di |
| author_facet | Shaobin Yu Ling Zhu Qiang Shen Xue Bai Xuhui Di |
| author_sort | Shaobin Yu |
| collection | DOAJ |
| description | Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine and amphetamine class of psychoactive drugs, which are widely abused for their stimulant, euphoric, empathogenic, and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotonin neurotransmission. Subsequent to these acute effects, METH produces persistent damage to dopamine and serotonin release in nerve terminals, gliosis, and apoptosis. This review summarized the numerous interdependent mechanisms including excessive dopamine, ubiquitin-proteasome system dysfunction, protein nitration, endoplasmic reticulum stress, p53 expression, inflammatory molecular, D3 receptor, microtubule deacetylation, and HIV-1 Tat protein that have been demonstrated to contribute to this damage. In addition, the feasible therapeutic strategies according to recent studies were also summarized ranging from drug and protein to gene level. |
| format | Article |
| id | doaj-art-34e4a40d677d4dcbb18ad72af5588f34 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-34e4a40d677d4dcbb18ad72af5588f342025-02-03T00:58:55ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/103969103969Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular PathophysiologyShaobin Yu0Ling Zhu1Qiang Shen2Xue Bai3Xuhui Di4Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, ChinaDepartment of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, ChinaDepartment of Neurology, Hospitals of The Armed Police Forces in Hebei, Shijiazhuang 050051, ChinaDepartment of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, ChinaDepartment of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, ChinaMethamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine and amphetamine class of psychoactive drugs, which are widely abused for their stimulant, euphoric, empathogenic, and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotonin neurotransmission. Subsequent to these acute effects, METH produces persistent damage to dopamine and serotonin release in nerve terminals, gliosis, and apoptosis. This review summarized the numerous interdependent mechanisms including excessive dopamine, ubiquitin-proteasome system dysfunction, protein nitration, endoplasmic reticulum stress, p53 expression, inflammatory molecular, D3 receptor, microtubule deacetylation, and HIV-1 Tat protein that have been demonstrated to contribute to this damage. In addition, the feasible therapeutic strategies according to recent studies were also summarized ranging from drug and protein to gene level.http://dx.doi.org/10.1155/2015/103969 |
| spellingShingle | Shaobin Yu Ling Zhu Qiang Shen Xue Bai Xuhui Di Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology Behavioural Neurology |
| title | Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology |
| title_full | Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology |
| title_fullStr | Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology |
| title_full_unstemmed | Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology |
| title_short | Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology |
| title_sort | recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology |
| url | http://dx.doi.org/10.1155/2015/103969 |
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