Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis
Background/Aim. Hepcidin, an iron regulatory hormone, is increased in response to inflammation and some infections. We investigated the relationships among serum prohepcidin, iron status, Helicobacter pylori infection status, and the presence of gastric mucosal atrophy. Methods. Seventy subjects und...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/201810 |
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| author | Hyung-Keun Kim Eun-Chul Jang Ju-Ok Yeom Sun-Young Kim Hyunjung Cho Sung Soo Kim Hiun-Suk Chae Young-Seok Cho |
| author_facet | Hyung-Keun Kim Eun-Chul Jang Ju-Ok Yeom Sun-Young Kim Hyunjung Cho Sung Soo Kim Hiun-Suk Chae Young-Seok Cho |
| author_sort | Hyung-Keun Kim |
| collection | DOAJ |
| description | Background/Aim. Hepcidin, an iron regulatory hormone, is increased in response to inflammation and some infections. We investigated the relationships among serum prohepcidin, iron status, Helicobacter pylori infection status, and the presence of gastric mucosal atrophy. Methods. Seventy subjects undergoing esophagogastroduodenoscopy underwent multiple gastric biopsies, and the possibility of H. pylori infection and the degree of endoscopic and histologic gastritis were investigated. In all subjects, serum prohepcidin and iron parameters were evaluated. Results. No correlations were observed between serum prohepcidin levels and the other markers of anemia, such as hemoglobin, serum iron, ferritin, and total iron binding capacity. Serum prohepcidin levels were not significantly different between the H. pylori-positive group and the H. pylori-negative group. Serum prohepcidin levels in atrophic gastritis patients were significantly lower than those in subjects without atrophic gastritis irrespective of H. pylori infection. Conclusion. Serum prohepcidin levels were not altered by H. pylori infection. Serum prohepcidin levels decrease in patients with atrophic gastritis, irrespective of H. pylori infection. It suggests that hepcidin may decrease due to gastric atrophy, a condition that causes a loss of hepcidin-producing parietal cells. Further investigations with a larger number of patients are necessary to substantiate this point. |
| format | Article |
| id | doaj-art-34dd778bf42143ccb9d4b6754c4e0a12 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-34dd778bf42143ccb9d4b6754c4e0a122025-02-03T05:44:28ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/201810201810Serum Prohepcidin Levels Are Lower in Patients with Atrophic GastritisHyung-Keun Kim0Eun-Chul Jang1Ju-Ok Yeom2Sun-Young Kim3Hyunjung Cho4Sung Soo Kim5Hiun-Suk Chae6Young-Seok Cho7Department of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of KoreaMOT Cluster, Korea University of Technology and Education, Cheonan 330708, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of KoreaBackground/Aim. Hepcidin, an iron regulatory hormone, is increased in response to inflammation and some infections. We investigated the relationships among serum prohepcidin, iron status, Helicobacter pylori infection status, and the presence of gastric mucosal atrophy. Methods. Seventy subjects undergoing esophagogastroduodenoscopy underwent multiple gastric biopsies, and the possibility of H. pylori infection and the degree of endoscopic and histologic gastritis were investigated. In all subjects, serum prohepcidin and iron parameters were evaluated. Results. No correlations were observed between serum prohepcidin levels and the other markers of anemia, such as hemoglobin, serum iron, ferritin, and total iron binding capacity. Serum prohepcidin levels were not significantly different between the H. pylori-positive group and the H. pylori-negative group. Serum prohepcidin levels in atrophic gastritis patients were significantly lower than those in subjects without atrophic gastritis irrespective of H. pylori infection. Conclusion. Serum prohepcidin levels were not altered by H. pylori infection. Serum prohepcidin levels decrease in patients with atrophic gastritis, irrespective of H. pylori infection. It suggests that hepcidin may decrease due to gastric atrophy, a condition that causes a loss of hepcidin-producing parietal cells. Further investigations with a larger number of patients are necessary to substantiate this point.http://dx.doi.org/10.1155/2013/201810 |
| spellingShingle | Hyung-Keun Kim Eun-Chul Jang Ju-Ok Yeom Sun-Young Kim Hyunjung Cho Sung Soo Kim Hiun-Suk Chae Young-Seok Cho Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis Gastroenterology Research and Practice |
| title | Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis |
| title_full | Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis |
| title_fullStr | Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis |
| title_full_unstemmed | Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis |
| title_short | Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis |
| title_sort | serum prohepcidin levels are lower in patients with atrophic gastritis |
| url | http://dx.doi.org/10.1155/2013/201810 |
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