Booster vaccines dose reduced mortality in hospitalized COVID-19 patients requiring oxygen supplementation: Evidence from the Beijing Omicron outbreak
To assess the impact of vaccines on clinical outcomes among hospitalized COVID-19-infected patients requiring oxygen supplementation during the Beijing Omicron outbreak. We conducted a retrospective cohort study at Beijing Chaoyang Hospital, Capital Medical University, from November 15, 2022, to Mar...
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2361500 |
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| author | Xinrui Wang Yi Zhang Chong Huang Hui Yang Chunguo Jiang Xiaojia Yu Rui Zhao Jun Hong Yi Zhang Yushu Wang Rui Zhao Zhuoling An Zhaohui Tong |
| author_facet | Xinrui Wang Yi Zhang Chong Huang Hui Yang Chunguo Jiang Xiaojia Yu Rui Zhao Jun Hong Yi Zhang Yushu Wang Rui Zhao Zhuoling An Zhaohui Tong |
| author_sort | Xinrui Wang |
| collection | DOAJ |
| description | To assess the impact of vaccines on clinical outcomes among hospitalized COVID-19-infected patients requiring oxygen supplementation during the Beijing Omicron outbreak. We conducted a retrospective cohort study at Beijing Chaoyang Hospital, Capital Medical University, from November 15, 2022, to March 31, 2023. Vaccination statuses were categorized into 3 doses, 2 doses, and unvaccinated (0 dose). The primary outcome was 28-day all-cause mortality. Secondary outcomes included poor outcomes, intensive care unit admission, cardiovascular thromboembolism events, and hospital readmission. Among the included patients, 117 were 2 doses, 285 received booster doses, and 503 were unvaccinated. After propensity score inverse probability weighting, the 3 doses group showed a significantly lower 28-day all-cause mortality compared to the unvaccinated group (inverse probability of treatment weighting-adjusted HR: 0.64, 95% CI: 0.50–0.81). No significant difference was observed in all-cause mortality between the 2 doses and unvaccinated groups. No significant differences were observed in secondary outcome analyses when comparing the 3 doses or 2 doses group to the unvaccinated group. Subgroup analysis revealed significant benefits of booster vaccination in patients with shorter symptom duration, lower Charlson Comorbidity Index, and without immunosuppression status. Our study highlights the significant reduction in all-cause mortality among hospitalized Omicron-infected patients who received a third dose vaccine. These findings underscore the importance of prioritizing booster vaccinations, especially among the elderly. Further research is warranted to confirm and extend these observations. |
| format | Article |
| id | doaj-art-34d23e8aaeab4357ac485bf6bc097bfb |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-34d23e8aaeab4357ac485bf6bc097bfb2025-08-20T03:21:46ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2361500Booster vaccines dose reduced mortality in hospitalized COVID-19 patients requiring oxygen supplementation: Evidence from the Beijing Omicron outbreakXinrui Wang0Yi Zhang1Chong Huang2Hui Yang3Chunguo Jiang4Xiaojia Yu5Rui Zhao6Jun Hong7Yi Zhang8Yushu Wang9Rui Zhao10Zhuoling An11Zhaohui Tong12Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaSchool of Pharmaceutical Sciences, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaSchool of Pharmaceutical Sciences, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaTo assess the impact of vaccines on clinical outcomes among hospitalized COVID-19-infected patients requiring oxygen supplementation during the Beijing Omicron outbreak. We conducted a retrospective cohort study at Beijing Chaoyang Hospital, Capital Medical University, from November 15, 2022, to March 31, 2023. Vaccination statuses were categorized into 3 doses, 2 doses, and unvaccinated (0 dose). The primary outcome was 28-day all-cause mortality. Secondary outcomes included poor outcomes, intensive care unit admission, cardiovascular thromboembolism events, and hospital readmission. Among the included patients, 117 were 2 doses, 285 received booster doses, and 503 were unvaccinated. After propensity score inverse probability weighting, the 3 doses group showed a significantly lower 28-day all-cause mortality compared to the unvaccinated group (inverse probability of treatment weighting-adjusted HR: 0.64, 95% CI: 0.50–0.81). No significant difference was observed in all-cause mortality between the 2 doses and unvaccinated groups. No significant differences were observed in secondary outcome analyses when comparing the 3 doses or 2 doses group to the unvaccinated group. Subgroup analysis revealed significant benefits of booster vaccination in patients with shorter symptom duration, lower Charlson Comorbidity Index, and without immunosuppression status. Our study highlights the significant reduction in all-cause mortality among hospitalized Omicron-infected patients who received a third dose vaccine. These findings underscore the importance of prioritizing booster vaccinations, especially among the elderly. Further research is warranted to confirm and extend these observations.https://www.tandfonline.com/doi/10.1080/21645515.2024.2361500COVID-19vaccinehospitalized patientsbooster vaccine dose |
| spellingShingle | Xinrui Wang Yi Zhang Chong Huang Hui Yang Chunguo Jiang Xiaojia Yu Rui Zhao Jun Hong Yi Zhang Yushu Wang Rui Zhao Zhuoling An Zhaohui Tong Booster vaccines dose reduced mortality in hospitalized COVID-19 patients requiring oxygen supplementation: Evidence from the Beijing Omicron outbreak Human Vaccines & Immunotherapeutics COVID-19 vaccine hospitalized patients booster vaccine dose |
| title | Booster vaccines dose reduced mortality in hospitalized COVID-19 patients requiring oxygen supplementation: Evidence from the Beijing Omicron outbreak |
| title_full | Booster vaccines dose reduced mortality in hospitalized COVID-19 patients requiring oxygen supplementation: Evidence from the Beijing Omicron outbreak |
| title_fullStr | Booster vaccines dose reduced mortality in hospitalized COVID-19 patients requiring oxygen supplementation: Evidence from the Beijing Omicron outbreak |
| title_full_unstemmed | Booster vaccines dose reduced mortality in hospitalized COVID-19 patients requiring oxygen supplementation: Evidence from the Beijing Omicron outbreak |
| title_short | Booster vaccines dose reduced mortality in hospitalized COVID-19 patients requiring oxygen supplementation: Evidence from the Beijing Omicron outbreak |
| title_sort | booster vaccines dose reduced mortality in hospitalized covid 19 patients requiring oxygen supplementation evidence from the beijing omicron outbreak |
| topic | COVID-19 vaccine hospitalized patients booster vaccine dose |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2361500 |
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