Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene
Abstract Biological applications of sumanene buckybowl molecule have been widely discussed over the years yet remain still unexplored experimentally. On the other hand, creating cyclodextrin-containing supramolecular assemblies was demonstrated to be a powerful tool in terms of designing effective s...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-78110-1 |
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| author | Artur Kasprzak Agnieszka Żuchowska Hidehiro Sakurai |
| author_facet | Artur Kasprzak Agnieszka Żuchowska Hidehiro Sakurai |
| author_sort | Artur Kasprzak |
| collection | DOAJ |
| description | Abstract Biological applications of sumanene buckybowl molecule have been widely discussed over the years yet remain still unexplored experimentally. On the other hand, creating cyclodextrin-containing supramolecular assemblies was demonstrated to be a powerful tool in terms of designing effective systems for medicinal chemistry purposes. Here, we show that sumanene molecule exclusively forms 1:1 host-guest complexes with γ-cyclodextrin (γCD) or (2-hydroxypropyl)-γ-cyclodextrin (HP-γCD), as revealed by extensive spectroscopic studies supported with density functional theory (DFT) computations. Based on our preliminary biological studies, we discovered that the formation of such complexes resulted in the improvement of anticancer properties of sumanene, expressed by high cell viabilities in vitro of healthy human mammary fibroblasts (HMF) together with low viabilities of human breast adenocarcinoma cells (MDA-MB-231). Improved pharmacokinetic (ADME-Tox) properties for sumanene@γCD and sumanene@HP-γCD complexes in comparison to native sumanene were also supported by in sillico modeling studies. This work provides the method how to focus the cytotoxic action of sumanene toward cancer cells using supramolecular assembly strategy, paving the way to the further exploration of biological properties of sumanene-containing supramolecular systems with bioactive features and applications of this buckybowl in general. |
| format | Article |
| id | doaj-art-34d040f014a843758438cdf489f12630 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-34d040f014a843758438cdf489f126302025-01-19T12:24:45ZengNature PortfolioScientific Reports2045-23222024-11-0114111210.1038/s41598-024-78110-1Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumaneneArtur Kasprzak0Agnieszka Żuchowska1Hidehiro Sakurai2Faculty of Chemistry, Warsaw University of TechnologyFaculty of Chemistry, Warsaw University of TechnologyDivision of Applied Chemistry, Graduate School of Engineering, Osaka UniversityAbstract Biological applications of sumanene buckybowl molecule have been widely discussed over the years yet remain still unexplored experimentally. On the other hand, creating cyclodextrin-containing supramolecular assemblies was demonstrated to be a powerful tool in terms of designing effective systems for medicinal chemistry purposes. Here, we show that sumanene molecule exclusively forms 1:1 host-guest complexes with γ-cyclodextrin (γCD) or (2-hydroxypropyl)-γ-cyclodextrin (HP-γCD), as revealed by extensive spectroscopic studies supported with density functional theory (DFT) computations. Based on our preliminary biological studies, we discovered that the formation of such complexes resulted in the improvement of anticancer properties of sumanene, expressed by high cell viabilities in vitro of healthy human mammary fibroblasts (HMF) together with low viabilities of human breast adenocarcinoma cells (MDA-MB-231). Improved pharmacokinetic (ADME-Tox) properties for sumanene@γCD and sumanene@HP-γCD complexes in comparison to native sumanene were also supported by in sillico modeling studies. This work provides the method how to focus the cytotoxic action of sumanene toward cancer cells using supramolecular assembly strategy, paving the way to the further exploration of biological properties of sumanene-containing supramolecular systems with bioactive features and applications of this buckybowl in general.https://doi.org/10.1038/s41598-024-78110-1 |
| spellingShingle | Artur Kasprzak Agnieszka Żuchowska Hidehiro Sakurai Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene Scientific Reports |
| title | Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene |
| title_full | Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene |
| title_fullStr | Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene |
| title_full_unstemmed | Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene |
| title_short | Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene |
| title_sort | complexation by γ cyclodextrin as a way of improving anticancer potential of sumanene |
| url | https://doi.org/10.1038/s41598-024-78110-1 |
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