Green Synthesis of Antibacterial CuO Nanoparticles Based on the Synergy Between <i>Cornu aspersum</i> Snail Mucus and Ascorbic Acid
Many biologically active compounds have been identified in the mucus of the garden snail <i>Cornu aspersum</i>, which are effective in the treatment of several diseases such as cancer, ulcers, wounds, etc. The incorporation of these compounds into the green synthesis of copper nanopartic...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/2/291 |
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| Summary: | Many biologically active compounds have been identified in the mucus of the garden snail <i>Cornu aspersum</i>, which are effective in the treatment of several diseases such as cancer, ulcers, wounds, etc. The incorporation of these compounds into the green synthesis of copper nanoparticles (CuONPs-Muc) was demonstrated in our previous study. Based on the synergistic effect of two reducing agents—<i>C. aspersum</i> snail mucus and ascorbic acid (AsA)—on CuSO<sub>4</sub>.5H<sub>2</sub>O, which also act as stabilizers of the resulting compound, a new method for the “green” synthesis of CuONPs-Muc is presented. Using two reducing agents has several advantages, such as forming spherical nanoparticles with a diameter of about 150 nm and reducing the formation time of CuONPs-Muc to 3 h. Analyses by ultraviolet–visible spectroscopy (UV-Vis) and Fourier transform infrared spectroscopy (FT-IR) show the formation of CuONPs-Muc, composed of a mixture of copper and copper oxide. This was confirmed by scanning electron microscopy combined with energy-dispersive spectroscopy (SEM/EDS) and X-ray diffraction (XRD). Another important advantage of CuONPs obtained by the new method with two reducing agents is the stronger inhibitory effect on the bacterial growth of some Gram-positive and Gram-negative bacterial strains, compared to CuONPs-Muc prepared with only one reducing agent, i.e., a fraction of mucus with an MW > 20 kDa. |
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| ISSN: | 1420-3049 |