Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of Phosphatidylserine as a Main Regulator
Leishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. The poor activation of an effective cellular response is correlated with the ability of these parasites to infect mononuclear...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2012/981686 |
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| _version_ | 1832567297383858176 |
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| author | Joao Luiz Mendes Wanderley Jaqueline França Costa Valéria Matos Borges Marcello Barcinski |
| author_facet | Joao Luiz Mendes Wanderley Jaqueline França Costa Valéria Matos Borges Marcello Barcinski |
| author_sort | Joao Luiz Mendes Wanderley |
| collection | DOAJ |
| description | Leishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. The poor activation of an effective cellular response is correlated with the ability of these parasites to infect mononuclear phagocytic cells without triggering their activation or actively suppressing innate responses of these cells. Here we discuss the possible role of phosphatidylserine exposure by these parasites as a main regulator of the mechanism underlying subversion of the immune system at different steps during the infection. |
| format | Article |
| id | doaj-art-34b2c748e311407ba87b987f51541c2c |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-34b2c748e311407ba87b987f51541c2c2025-02-03T01:01:52ZengWileyJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/981686981686Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of Phosphatidylserine as a Main RegulatorJoao Luiz Mendes Wanderley0Jaqueline França Costa1Valéria Matos Borges2Marcello Barcinski3Universidade Federal do Rio de Janeiro, Pólo Universitário Macaé, BrazilCentro de Pesquisa Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, BrazilCentro de Pesquisa Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, BrazilLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, BrazilLeishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. The poor activation of an effective cellular response is correlated with the ability of these parasites to infect mononuclear phagocytic cells without triggering their activation or actively suppressing innate responses of these cells. Here we discuss the possible role of phosphatidylserine exposure by these parasites as a main regulator of the mechanism underlying subversion of the immune system at different steps during the infection.http://dx.doi.org/10.1155/2012/981686 |
| spellingShingle | Joao Luiz Mendes Wanderley Jaqueline França Costa Valéria Matos Borges Marcello Barcinski Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of Phosphatidylserine as a Main Regulator Journal of Parasitology Research |
| title | Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of
Phosphatidylserine as a Main Regulator |
| title_full | Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of
Phosphatidylserine as a Main Regulator |
| title_fullStr | Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of
Phosphatidylserine as a Main Regulator |
| title_full_unstemmed | Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of
Phosphatidylserine as a Main Regulator |
| title_short | Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of
Phosphatidylserine as a Main Regulator |
| title_sort | subversion of immunity by leishmania amazonensis parasites possible role of phosphatidylserine as a main regulator |
| url | http://dx.doi.org/10.1155/2012/981686 |
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