Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection
Two dogs, with naturally acquired canine leishmaniasis, were treated orally with miltefosine (2 mg/kg q 24 hr) and allopurinol (10 mg/kg q 12 hr) for 28 days. Both dogs showed good initial response to therapy, with reduction in clinical signs and improvement of clinicopathological changes. However,...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Veterinary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/640151 |
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| author | Daniela Proverbio Eva Spada Giada Bagnagatti De Giorgi Roberta Perego |
| author_facet | Daniela Proverbio Eva Spada Giada Bagnagatti De Giorgi Roberta Perego |
| author_sort | Daniela Proverbio |
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| description | Two dogs, with naturally acquired canine leishmaniasis, were treated orally with miltefosine (2 mg/kg q 24 hr) and allopurinol (10 mg/kg q 12 hr) for 28 days. Both dogs showed good initial response to therapy, with reduction in clinical signs and improvement of clinicopathological changes. However, in both dogs, clinical and clinicopathological abnormalities recurred 150 days after initial treatment and a second course of miltefosine and allopurinol was administered. One dog failed to respond to the 2nd cycle of miltefosine treatment and the other dog responded initially but suffered an early relapse. Treatment with meglumine antimoniate (100 mg/kg q 24 hr for a minimum of 4 weeks) was then started in both dogs. Both dogs showed rapid clinical and clinicopathological improvement and to date they have not received further treatment for 420 and 270 days, respectively. In view of the low number of antileishmanial drugs available and the fact that some of these are used in human as well as veterinary medicine, it is of paramount importance that drug resistance is monitored and documented. |
| format | Article |
| id | doaj-art-3491c1474221483d8eb2a2919bd0b5e6 |
| institution | Kabale University |
| issn | 2090-7001 2090-701X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Veterinary Medicine |
| spelling | doaj-art-3491c1474221483d8eb2a2919bd0b5e62025-02-03T01:23:41ZengWileyCase Reports in Veterinary Medicine2090-70012090-701X2014-01-01201410.1155/2014/640151640151Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum InfectionDaniela Proverbio0Eva Spada1Giada Bagnagatti De Giorgi2Roberta Perego3Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, Università degli Studi di Milano, Via G. Celoria, 10-20133 Milano, ItalyDipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, Università degli Studi di Milano, Via G. Celoria, 10-20133 Milano, ItalyDipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, Università degli Studi di Milano, Via G. Celoria, 10-20133 Milano, ItalyDipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, Università degli Studi di Milano, Via G. Celoria, 10-20133 Milano, ItalyTwo dogs, with naturally acquired canine leishmaniasis, were treated orally with miltefosine (2 mg/kg q 24 hr) and allopurinol (10 mg/kg q 12 hr) for 28 days. Both dogs showed good initial response to therapy, with reduction in clinical signs and improvement of clinicopathological changes. However, in both dogs, clinical and clinicopathological abnormalities recurred 150 days after initial treatment and a second course of miltefosine and allopurinol was administered. One dog failed to respond to the 2nd cycle of miltefosine treatment and the other dog responded initially but suffered an early relapse. Treatment with meglumine antimoniate (100 mg/kg q 24 hr for a minimum of 4 weeks) was then started in both dogs. Both dogs showed rapid clinical and clinicopathological improvement and to date they have not received further treatment for 420 and 270 days, respectively. In view of the low number of antileishmanial drugs available and the fact that some of these are used in human as well as veterinary medicine, it is of paramount importance that drug resistance is monitored and documented.http://dx.doi.org/10.1155/2014/640151 |
| spellingShingle | Daniela Proverbio Eva Spada Giada Bagnagatti De Giorgi Roberta Perego Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection Case Reports in Veterinary Medicine |
| title | Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection |
| title_full | Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection |
| title_fullStr | Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection |
| title_full_unstemmed | Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection |
| title_short | Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection |
| title_sort | failure of miltefosine treatment in two dogs with natural leishmania infantum infection |
| url | http://dx.doi.org/10.1155/2014/640151 |
| work_keys_str_mv | AT danielaproverbio failureofmiltefosinetreatmentintwodogswithnaturalleishmaniainfantuminfection AT evaspada failureofmiltefosinetreatmentintwodogswithnaturalleishmaniainfantuminfection AT giadabagnagattidegiorgi failureofmiltefosinetreatmentintwodogswithnaturalleishmaniainfantuminfection AT robertaperego failureofmiltefosinetreatmentintwodogswithnaturalleishmaniainfantuminfection |