Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants
Various forms of cancer are rising all over the world, requiring newer therapy. The quest of anticancer drugs both from natural and synthetic sources is the demand of time. In this study, fourteen extracts of different parts of eleven Bangladeshi medicinal plants which have been traditionally used f...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/913127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556947527696384 |
|---|---|
| author | Amina Khatun Mahmudur Rahman Tania Haque Md. Mahfizur Rahman Mahfuja Akter Subarna Akter Afrin Jhumur |
| author_facet | Amina Khatun Mahmudur Rahman Tania Haque Md. Mahfizur Rahman Mahfuja Akter Subarna Akter Afrin Jhumur |
| author_sort | Amina Khatun |
| collection | DOAJ |
| description | Various forms of cancer are rising all over the world, requiring newer therapy. The quest of anticancer drugs both from natural and synthetic sources is the demand of time. In this study, fourteen extracts of different parts of eleven Bangladeshi medicinal plants which have been traditionally used for the treatment of different types of carcinoma, tumor, leprosy, and diseases associated with cancer were evaluated for their cytotoxicity for the first time. Extraction was conceded using methanol. Phytochemical groups like reducing sugars, tannins, saponins, steroids, gums, flavonoids, and alkaloids were tested using standard chromogenic reagents. Plants were evaluated for cytotoxicity by brine shrimp lethality bioassay using Artemia salina comparing with standard anticancer drug vincristine sulphate. All the extracts showed potent to moderate cytotoxicity ranging from LC50 2 to 115 µg/mL. The highest toxicity was shown by Hygrophila spinosa seeds (LC50=2.93 µg/mL) and the lowest by Litsea glutinosa leaves (LC50=114.71 µg/mL) in comparison with standard vincristine sulphate (LC50=2.04 µg/mL). Among the plants, the plants traditionally used in different cancer and microbial treatments showed highest cytotoxicity.
The results support their ethnomedicinal uses and require advanced investigation to elucidate responsible compounds as well as their mode of action. |
| format | Article |
| id | doaj-art-3481627fdba74f859001901877258630 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-3481627fdba74f8590019018772586302025-02-03T05:43:57ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/913127913127Cytotoxicity Potentials of Eleven Bangladeshi Medicinal PlantsAmina Khatun0Mahmudur Rahman1Tania Haque2Md. Mahfizur Rahman3Mahfuja Akter4Subarna Akter5Afrin Jhumur6Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, BangladeshNatural Product and Drug Discovery Lab, Department of Pharmacy, Faculty of Health Sciences, Northern University Bangladesh, 24 Mirpur Road, Dhaka 1205, BangladeshPhytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, BangladeshPhytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, BangladeshPhytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, BangladeshPhytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, BangladeshPhytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, School of Science, Engineering and Technology, Manarat International University, 1/B, 1/1, Zoo Road, Mirpur, Dhaka 1216, BangladeshVarious forms of cancer are rising all over the world, requiring newer therapy. The quest of anticancer drugs both from natural and synthetic sources is the demand of time. In this study, fourteen extracts of different parts of eleven Bangladeshi medicinal plants which have been traditionally used for the treatment of different types of carcinoma, tumor, leprosy, and diseases associated with cancer were evaluated for their cytotoxicity for the first time. Extraction was conceded using methanol. Phytochemical groups like reducing sugars, tannins, saponins, steroids, gums, flavonoids, and alkaloids were tested using standard chromogenic reagents. Plants were evaluated for cytotoxicity by brine shrimp lethality bioassay using Artemia salina comparing with standard anticancer drug vincristine sulphate. All the extracts showed potent to moderate cytotoxicity ranging from LC50 2 to 115 µg/mL. The highest toxicity was shown by Hygrophila spinosa seeds (LC50=2.93 µg/mL) and the lowest by Litsea glutinosa leaves (LC50=114.71 µg/mL) in comparison with standard vincristine sulphate (LC50=2.04 µg/mL). Among the plants, the plants traditionally used in different cancer and microbial treatments showed highest cytotoxicity. The results support their ethnomedicinal uses and require advanced investigation to elucidate responsible compounds as well as their mode of action.http://dx.doi.org/10.1155/2014/913127 |
| spellingShingle | Amina Khatun Mahmudur Rahman Tania Haque Md. Mahfizur Rahman Mahfuja Akter Subarna Akter Afrin Jhumur Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants The Scientific World Journal |
| title | Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants |
| title_full | Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants |
| title_fullStr | Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants |
| title_full_unstemmed | Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants |
| title_short | Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants |
| title_sort | cytotoxicity potentials of eleven bangladeshi medicinal plants |
| url | http://dx.doi.org/10.1155/2014/913127 |
| work_keys_str_mv | AT aminakhatun cytotoxicitypotentialsofelevenbangladeshimedicinalplants AT mahmudurrahman cytotoxicitypotentialsofelevenbangladeshimedicinalplants AT taniahaque cytotoxicitypotentialsofelevenbangladeshimedicinalplants AT mdmahfizurrahman cytotoxicitypotentialsofelevenbangladeshimedicinalplants AT mahfujaakter cytotoxicitypotentialsofelevenbangladeshimedicinalplants AT subarnaakter cytotoxicitypotentialsofelevenbangladeshimedicinalplants AT afrinjhumur cytotoxicitypotentialsofelevenbangladeshimedicinalplants |