Anticancer and Free Radical Scavenging Competence of Zinc Oxide Nanoparticles Synthesized by Aqueous Leaf Extract of Phyllanthus acidus
The purpose of this study was aimed to investigate the zinc oxide nanoparticles (ZnONPs) synthesizing efficiency of aqueous leaf extract of Phyllanthus acidus. Furthermore, the antioxidant and anticancer activities of synthesized ZnONPs were also investigated through the in-vitro approach. The obtai...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2022/9493816 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548318057594880 |
|---|---|
| author | Arunachalam Chinnathambi Sulaiman Ali Alharbi Deepika Joshi Haiter Lenin |
| author_facet | Arunachalam Chinnathambi Sulaiman Ali Alharbi Deepika Joshi Haiter Lenin |
| author_sort | Arunachalam Chinnathambi |
| collection | DOAJ |
| description | The purpose of this study was aimed to investigate the zinc oxide nanoparticles (ZnONPs) synthesizing efficiency of aqueous leaf extract of Phyllanthus acidus. Furthermore, the antioxidant and anticancer activities of synthesized ZnONPs were also investigated through the in-vitro approach. The obtained results show that the aqueous extract of P. acidus can synthesize ZnONPs, as evidenced by a sharp absorbance peak at 375 nm. The Fourier transform infrared spectroscopy (FTIR) analysis confirmed that the aqueous extract contained significant numbers of functional groups, which were involved in reducing zinc nitrate into ZnONPs. Also, they participate in the capping and stabilization of synthesized ZnONPs and their size ranged from 27.14–35.74 nm with a spherical shape . The results obtained in ABTS radical scavenging activity 1, 1-diphenyl-2-picryl-hydroxyl (DPPH), hydrogen peroxide (H2O2), and 2,2′-Azino-Bis(3-ethylbenzene thiazoline-6-sulfonic acid) (ABTS) assays declared has excellent in-vitro radicals scavenging activity with reasonable IC50 values. Interestingly, these green synthesized ZnONPs have an excellent anticancer activity against human epidermoid carcinoma (Hep3) cell line in an in-vitro approach. These findings imply that an aqueous leaf extract of P. acidus can be used to synthesize pharmaceutically valuable ZnONPs. To consider such nanomaterials as potential therapeutic agents, optimization and in-vivo biomedical studies are required. |
| format | Article |
| id | doaj-art-3470ce22905144b180b1efcf8c14a02f |
| institution | Kabale University |
| issn | 1687-479X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-3470ce22905144b180b1efcf8c14a02f2025-02-03T06:14:53ZengWileyBioinorganic Chemistry and Applications1687-479X2022-01-01202210.1155/2022/9493816Anticancer and Free Radical Scavenging Competence of Zinc Oxide Nanoparticles Synthesized by Aqueous Leaf Extract of Phyllanthus acidusArunachalam Chinnathambi0Sulaiman Ali Alharbi1Deepika Joshi2Haiter Lenin3Department of Botany and MicrobiologyDepartment of Botany and MicrobiologyDepartment of Oral BiologyDepartment of Mechanical EngineeringThe purpose of this study was aimed to investigate the zinc oxide nanoparticles (ZnONPs) synthesizing efficiency of aqueous leaf extract of Phyllanthus acidus. Furthermore, the antioxidant and anticancer activities of synthesized ZnONPs were also investigated through the in-vitro approach. The obtained results show that the aqueous extract of P. acidus can synthesize ZnONPs, as evidenced by a sharp absorbance peak at 375 nm. The Fourier transform infrared spectroscopy (FTIR) analysis confirmed that the aqueous extract contained significant numbers of functional groups, which were involved in reducing zinc nitrate into ZnONPs. Also, they participate in the capping and stabilization of synthesized ZnONPs and their size ranged from 27.14–35.74 nm with a spherical shape . The results obtained in ABTS radical scavenging activity 1, 1-diphenyl-2-picryl-hydroxyl (DPPH), hydrogen peroxide (H2O2), and 2,2′-Azino-Bis(3-ethylbenzene thiazoline-6-sulfonic acid) (ABTS) assays declared has excellent in-vitro radicals scavenging activity with reasonable IC50 values. Interestingly, these green synthesized ZnONPs have an excellent anticancer activity against human epidermoid carcinoma (Hep3) cell line in an in-vitro approach. These findings imply that an aqueous leaf extract of P. acidus can be used to synthesize pharmaceutically valuable ZnONPs. To consider such nanomaterials as potential therapeutic agents, optimization and in-vivo biomedical studies are required.http://dx.doi.org/10.1155/2022/9493816 |
| spellingShingle | Arunachalam Chinnathambi Sulaiman Ali Alharbi Deepika Joshi Haiter Lenin Anticancer and Free Radical Scavenging Competence of Zinc Oxide Nanoparticles Synthesized by Aqueous Leaf Extract of Phyllanthus acidus Bioinorganic Chemistry and Applications |
| title | Anticancer and Free Radical Scavenging Competence of Zinc Oxide Nanoparticles Synthesized by Aqueous Leaf Extract of Phyllanthus acidus |
| title_full | Anticancer and Free Radical Scavenging Competence of Zinc Oxide Nanoparticles Synthesized by Aqueous Leaf Extract of Phyllanthus acidus |
| title_fullStr | Anticancer and Free Radical Scavenging Competence of Zinc Oxide Nanoparticles Synthesized by Aqueous Leaf Extract of Phyllanthus acidus |
| title_full_unstemmed | Anticancer and Free Radical Scavenging Competence of Zinc Oxide Nanoparticles Synthesized by Aqueous Leaf Extract of Phyllanthus acidus |
| title_short | Anticancer and Free Radical Scavenging Competence of Zinc Oxide Nanoparticles Synthesized by Aqueous Leaf Extract of Phyllanthus acidus |
| title_sort | anticancer and free radical scavenging competence of zinc oxide nanoparticles synthesized by aqueous leaf extract of phyllanthus acidus |
| url | http://dx.doi.org/10.1155/2022/9493816 |
| work_keys_str_mv | AT arunachalamchinnathambi anticancerandfreeradicalscavengingcompetenceofzincoxidenanoparticlessynthesizedbyaqueousleafextractofphyllanthusacidus AT sulaimanalialharbi anticancerandfreeradicalscavengingcompetenceofzincoxidenanoparticlessynthesizedbyaqueousleafextractofphyllanthusacidus AT deepikajoshi anticancerandfreeradicalscavengingcompetenceofzincoxidenanoparticlessynthesizedbyaqueousleafextractofphyllanthusacidus AT haiterlenin anticancerandfreeradicalscavengingcompetenceofzincoxidenanoparticlessynthesizedbyaqueousleafextractofphyllanthusacidus |