Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens?
In June 2024, WHO released ‘Key updates to the treatment of drug-resistant tuberculosis: rapid communication’, after the preliminary publication of results from two clinical trials: ‘BEAT-Tuberculosis’ and ‘endTB’. All proposed regimens include clofazimine (Cfz). However, a recent paper has reported...
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| Format: | Article |
| Language: | English |
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International Union Against Tuberculosis and Lung Disease (The Union)
2024-11-01
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| Series: | IJTLD Open |
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| Online Access: | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000011/art00002 |
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| author | E. Pontali M. Raviglione |
| author_facet | E. Pontali M. Raviglione |
| author_sort | E. Pontali |
| collection | DOAJ |
| description | In June 2024, WHO released ‘Key updates to the treatment of drug-resistant tuberculosis: rapid communication’, after the preliminary publication of results from two clinical trials: ‘BEAT-Tuberculosis’ and ‘endTB’. All proposed regimens include clofazimine (Cfz). However, a recent paper has reported a high incidence of QTc prolongation among patients receiving Cfz-based treatment for multidrug-resistant TB in Taiwan. Here, we discuss the cardiac safety of Cfz and the role of active drug safety monitoring at the programme level in collecting information on this issue. |
| format | Article |
| id | doaj-art-346ff7d12c684af59cb861838a47d668 |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-346ff7d12c684af59cb861838a47d6682025-01-23T13:39:03ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902024-11-0111148648910.5588/ijtldopen.24.04902Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens?E. Pontali0M. Raviglione1Department of Infectious Diseases, Galliera Hospital, Genoa, Italy;MACH Centre, Università di Milano, Milan, Italy.In June 2024, WHO released ‘Key updates to the treatment of drug-resistant tuberculosis: rapid communication’, after the preliminary publication of results from two clinical trials: ‘BEAT-Tuberculosis’ and ‘endTB’. All proposed regimens include clofazimine (Cfz). However, a recent paper has reported a high incidence of QTc prolongation among patients receiving Cfz-based treatment for multidrug-resistant TB in Taiwan. Here, we discuss the cardiac safety of Cfz and the role of active drug safety monitoring at the programme level in collecting information on this issue.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000011/art00002qtc prolongationcfztuberculosismdr-tbxdr-tbadsm |
| spellingShingle | E. Pontali M. Raviglione Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? IJTLD Open qtc prolongation cfz tuberculosis mdr-tb xdr-tb adsm |
| title | Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? |
| title_full | Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? |
| title_fullStr | Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? |
| title_full_unstemmed | Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? |
| title_short | Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? |
| title_sort | updated treatment guidelines for drug resistant tb how safe are clofazimine based regimens |
| topic | qtc prolongation cfz tuberculosis mdr-tb xdr-tb adsm |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000011/art00002 |
| work_keys_str_mv | AT epontali updatedtreatmentguidelinesfordrugresistanttbhowsafeareclofaziminebasedregimens AT mraviglione updatedtreatmentguidelinesfordrugresistanttbhowsafeareclofaziminebasedregimens |