The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity
B regulatory cells (Bregs) belong to a subgroup of activated B cells tasked with maintaining self-tolerance and preventing autoimmunity. While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/254245 |
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| author | Zahava Vadasz Regina Peri Nasren Eiza Gleb Slobodin Alexandra Balbir-Gurman Elias Toubi |
| author_facet | Zahava Vadasz Regina Peri Nasren Eiza Gleb Slobodin Alexandra Balbir-Gurman Elias Toubi |
| author_sort | Zahava Vadasz |
| collection | DOAJ |
| description | B regulatory cells (Bregs) belong to a subgroup of activated B cells tasked with maintaining self-tolerance and preventing autoimmunity. While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, and PDL-1. In this study we show, for the first time, the expansion of CD25highFoxP3high Bregs in systemic lupus erythematosus (SLE) patients compared to healthy individuals (18.5 ± 3.052% versus 11.0 ± 1.654%, p<0.001, resp.). This expansion was also shown to correlate with SLE disease activity (r=0.75). In addition, CD25highFoxP3high Bregs were also IL-10high expressing and further expanded when stimulated with semaphorin 3A. In sum we show that CD25highFoxP3high are an additional subtype of Bregs, involved in regulating SLE disease activity. Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients. Further studies are required in order to assess the relation between high serum IL-10 and CD25highFoxP3high Breg cells. |
| format | Article |
| id | doaj-art-34534d5dc41a4669905143465889f814 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-34534d5dc41a4669905143465889f8142025-02-03T06:07:18ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/254245254245The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease ActivityZahava Vadasz0Regina Peri1Nasren Eiza2Gleb Slobodin3Alexandra Balbir-Gurman4Elias Toubi5Division of Allergy & Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, IsraelDivision of Allergy & Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, IsraelDivision of Allergy & Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, IsraelRheumatology Unit, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, IsraelB. Shine Rheumatology Unit, Rambam Health Care Campus, Faculty of Medicine, Technion, 4940 Haifa, IsraelDivision of Allergy & Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, IsraelB regulatory cells (Bregs) belong to a subgroup of activated B cells tasked with maintaining self-tolerance and preventing autoimmunity. While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, and PDL-1. In this study we show, for the first time, the expansion of CD25highFoxP3high Bregs in systemic lupus erythematosus (SLE) patients compared to healthy individuals (18.5 ± 3.052% versus 11.0 ± 1.654%, p<0.001, resp.). This expansion was also shown to correlate with SLE disease activity (r=0.75). In addition, CD25highFoxP3high Bregs were also IL-10high expressing and further expanded when stimulated with semaphorin 3A. In sum we show that CD25highFoxP3high are an additional subtype of Bregs, involved in regulating SLE disease activity. Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients. Further studies are required in order to assess the relation between high serum IL-10 and CD25highFoxP3high Breg cells.http://dx.doi.org/10.1155/2015/254245 |
| spellingShingle | Zahava Vadasz Regina Peri Nasren Eiza Gleb Slobodin Alexandra Balbir-Gurman Elias Toubi The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity Journal of Immunology Research |
| title | The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity |
| title_full | The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity |
| title_fullStr | The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity |
| title_full_unstemmed | The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity |
| title_short | The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity |
| title_sort | expansion of cd25highil 10highfoxp3high b regulatory cells is in association with sle disease activity |
| url | http://dx.doi.org/10.1155/2015/254245 |
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