Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice
Background and aim: Low-dose and long-term administration of macrolide antibiotics into patients with chronic airway inflammatory diseases could favorably modify their clinical conditions. However, the therapeutic mode of action of macrolides is not well understood. Free oxygen radicals, including n...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Mediators of Inflammation |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09629350310001599620 |
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| _version_ | 1832563761805787136 |
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| author | Hajime Terao Kazuhito Asano Ken-ichi Kanai Yoshiyuki Kyo So Watanabe Tadashi Hisamitsu Harumi Suzaki |
| author_facet | Hajime Terao Kazuhito Asano Ken-ichi Kanai Yoshiyuki Kyo So Watanabe Tadashi Hisamitsu Harumi Suzaki |
| author_sort | Hajime Terao |
| collection | DOAJ |
| description | Background and aim: Low-dose and long-term administration of macrolide antibiotics into patients with chronic airway inflammatory diseases could favorably modify their clinical conditions. However, the therapeutic mode of action of macrolides is not well understood. Free oxygen radicals, including nitric oxide (NO), are well recognized as the important final effector molecules in the development and the maintenance of inflammatory diseases. |
| format | Article |
| id | doaj-art-343d040a3f804114872ca450b7f125b9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-343d040a3f804114872ca450b7f125b92025-02-03T01:12:37ZengWileyMediators of Inflammation0962-93511466-18612003-01-0112419520210.1080/09629350310001599620Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in miceHajime Terao0Kazuhito Asano1Ken-ichi Kanai2Yoshiyuki Kyo3So Watanabe4Tadashi Hisamitsu5Harumi Suzaki6Department of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, JapanDepartment of Physiology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, JapanDepartment of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, JapanDepartment of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, JapanDepartment of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, JapanDepartment of Physiology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, JapanDepartment of Otolaryngology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8666, JapanBackground and aim: Low-dose and long-term administration of macrolide antibiotics into patients with chronic airway inflammatory diseases could favorably modify their clinical conditions. However, the therapeutic mode of action of macrolides is not well understood. Free oxygen radicals, including nitric oxide (NO), are well recognized as the important final effector molecules in the development and the maintenance of inflammatory diseases.http://dx.doi.org/10.1080/09629350310001599620Macrolide antibioticsNitric oxideMouseInducible nitric oxide synthase mRNAPro-inflammatory cytokineSuppressionIn vivo. |
| spellingShingle | Hajime Terao Kazuhito Asano Ken-ichi Kanai Yoshiyuki Kyo So Watanabe Tadashi Hisamitsu Harumi Suzaki Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice Mediators of Inflammation Macrolide antibiotics Nitric oxide Mouse Inducible nitric oxide synthase mRNA Pro-inflammatory cytokine Suppression In vivo. |
| title | Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice |
| title_full | Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice |
| title_fullStr | Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice |
| title_full_unstemmed | Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice |
| title_short | Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice |
| title_sort | suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice |
| topic | Macrolide antibiotics Nitric oxide Mouse Inducible nitric oxide synthase mRNA Pro-inflammatory cytokine Suppression In vivo. |
| url | http://dx.doi.org/10.1080/09629350310001599620 |
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