Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl Complexes
Phenalenyl (PLY)-based metal complexes are a new addition to the metal complex family. Various applications of metal-based phenalenyl complexes (metal-PLY) have been reported, such as catalyst, quantum spin simulators, spin electronic devices, and molecular conductors, but the biological significanc...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2022/8453159 |
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| author | Subhadeep Sen Nilkanta Chowdhury Tae-Wan Kim Mohuya Paul Dilip Debnath Seob Jeon Angshuman Bagchi Jungkyun Im Goutam Biswas |
| author_facet | Subhadeep Sen Nilkanta Chowdhury Tae-Wan Kim Mohuya Paul Dilip Debnath Seob Jeon Angshuman Bagchi Jungkyun Im Goutam Biswas |
| author_sort | Subhadeep Sen |
| collection | DOAJ |
| description | Phenalenyl (PLY)-based metal complexes are a new addition to the metal complex family. Various applications of metal-based phenalenyl complexes (metal-PLY) have been reported, such as catalyst, quantum spin simulators, spin electronic devices, and molecular conductors, but the biological significance of metal-PLY (metal = Co(II), Mn(III), Ni(II), Fe(III), and Al(III)) systems has yet to be explored. In this study, the anticancer properties of such complexes were investigated in ovarian cancer cells (SKOV3 and HEY A8), and the cytotoxicity was comparable to that of other platinum-based drugs. Antibacterial activity of the metal-PLY complexes against both gram-negative (E. coli) and gram-positive (S. aureus) bacteria was studied using a disk diffusion test and minimum inhibitory concentration (MIC) methods. All five metal-PLY complexes showed significant antibacterial activity against both bacterial strains. The antioxidant properties of metal-PLY complexes were evaluated following the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging method and were acceptable. The DNA-binding properties of these metal-PLY complexes were investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements, and thermal denaturation methods. Experimental evidence revealed that the complexes bind to DNA through intercalation, and the molecular docking study supported this conclusion. |
| format | Article |
| id | doaj-art-3436f3e3888e4d1c9fe456f60838c838 |
| institution | Kabale University |
| issn | 1687-479X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-3436f3e3888e4d1c9fe456f60838c8382025-02-03T06:05:51ZengWileyBioinorganic Chemistry and Applications1687-479X2022-01-01202210.1155/2022/8453159Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl ComplexesSubhadeep Sen0Nilkanta Chowdhury1Tae-Wan Kim2Mohuya Paul3Dilip Debnath4Seob Jeon5Angshuman Bagchi6Jungkyun Im7Goutam Biswas8Department of ChemistryDepartment of Biochemistry and BiophysicsDepartment of Medical Life ScienceDepartment of Electronic MaterialsDepartment of ChemistryDepartment of Obstetrics and GynecologyDepartment of Biochemistry and BiophysicsDepartment of Electronic MaterialsDepartment of ChemistryPhenalenyl (PLY)-based metal complexes are a new addition to the metal complex family. Various applications of metal-based phenalenyl complexes (metal-PLY) have been reported, such as catalyst, quantum spin simulators, spin electronic devices, and molecular conductors, but the biological significance of metal-PLY (metal = Co(II), Mn(III), Ni(II), Fe(III), and Al(III)) systems has yet to be explored. In this study, the anticancer properties of such complexes were investigated in ovarian cancer cells (SKOV3 and HEY A8), and the cytotoxicity was comparable to that of other platinum-based drugs. Antibacterial activity of the metal-PLY complexes against both gram-negative (E. coli) and gram-positive (S. aureus) bacteria was studied using a disk diffusion test and minimum inhibitory concentration (MIC) methods. All five metal-PLY complexes showed significant antibacterial activity against both bacterial strains. The antioxidant properties of metal-PLY complexes were evaluated following the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging method and were acceptable. The DNA-binding properties of these metal-PLY complexes were investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements, and thermal denaturation methods. Experimental evidence revealed that the complexes bind to DNA through intercalation, and the molecular docking study supported this conclusion.http://dx.doi.org/10.1155/2022/8453159 |
| spellingShingle | Subhadeep Sen Nilkanta Chowdhury Tae-Wan Kim Mohuya Paul Dilip Debnath Seob Jeon Angshuman Bagchi Jungkyun Im Goutam Biswas Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl Complexes Bioinorganic Chemistry and Applications |
| title | Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl Complexes |
| title_full | Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl Complexes |
| title_fullStr | Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl Complexes |
| title_full_unstemmed | Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl Complexes |
| title_short | Anticancer, Antibacterial, Antioxidant, and DNA-Binding Study of Metal-Phenalenyl Complexes |
| title_sort | anticancer antibacterial antioxidant and dna binding study of metal phenalenyl complexes |
| url | http://dx.doi.org/10.1155/2022/8453159 |
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