Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases
Introduction. We herein present three cases of locally advanced colon cancer (LACC) invading the urinary bladder, in whom combined neoadjuvant chemotherapy with surgical intervention was effective in disease control and preserving urinary function. Case Presentation. Before neoadjuvant chemotherapy,...
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| Format: | Article |
| Language: | English |
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2019-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2019/8129358 |
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| author | Tsutomu Takenami Shingo Tsujinaka Jun Takahashi Sawako Tamaki Ryo Maemoto Rintaro Fukuda Hideki Ishikawa Nao Kakizawa Fumi Hasegawa Rina Kikugawa Yasuyuki Miyakura Koichi Suzuki Akira Tanaka Toshiki Rikiyama |
| author_facet | Tsutomu Takenami Shingo Tsujinaka Jun Takahashi Sawako Tamaki Ryo Maemoto Rintaro Fukuda Hideki Ishikawa Nao Kakizawa Fumi Hasegawa Rina Kikugawa Yasuyuki Miyakura Koichi Suzuki Akira Tanaka Toshiki Rikiyama |
| author_sort | Tsutomu Takenami |
| collection | DOAJ |
| description | Introduction. We herein present three cases of locally advanced colon cancer (LACC) invading the urinary bladder, in whom combined neoadjuvant chemotherapy with surgical intervention was effective in disease control and preserving urinary function. Case Presentation. Before neoadjuvant chemotherapy, all three cases underwent loop transverse colostomy for symptomatic colonic obstruction. Case 1: after 6 courses of capecitabine plus oxaliplatin (CAPOX), we performed sigmoid colectomy and partial resection of the bladder. The histological examination revealed pathological complete response (pCR). The final diagnosis was ypStage 0 (ypT0ypN0M0). Case 2: after 13 courses of CAPOX plus bevacizumab, we performed Hartmann’s operation with partial resection of the bladder. The histological examination revealed pCR. The final diagnosis was ypStage 0 (ypT0ypN0M0). Case 3: after 6 courses of chemotherapy with CAPOX plus bevacizumab, we performed sigmoid colectomy and partial resection of the bladder. The pathological response was grade 1a according to the Japanese Classification of Colorectal Carcinoma. The final diagnosis was ypStage IIC (ypT4bypN0M0). All three cases underwent capecitabine-based adjuvant chemotherapy after radical surgery and patients are alive without recurrence. Conclusion. Neoadjuvant chemotherapy with CAPOX with or without bevacizumab followed by radical surgery could be an effective treatment option for LACC invading the urinary bladder. |
| format | Article |
| id | doaj-art-34332899bf9c4b85941d279ee9132113 |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-34332899bf9c4b85941d279ee91321132025-02-03T05:54:40ZengWileyCase Reports in Surgery2090-69002090-69192019-01-01201910.1155/2019/81293588129358Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three CasesTsutomu Takenami0Shingo Tsujinaka1Jun Takahashi2Sawako Tamaki3Ryo Maemoto4Rintaro Fukuda5Hideki Ishikawa6Nao Kakizawa7Fumi Hasegawa8Rina Kikugawa9Yasuyuki Miyakura10Koichi Suzuki11Akira Tanaka12Toshiki Rikiyama13Department of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanDepartment of Pathology, Saitama Medical Center, Jichi Medical University, JapanDepartment of Surgery, Saitama Medical Center, Jichi Medical University, JapanIntroduction. We herein present three cases of locally advanced colon cancer (LACC) invading the urinary bladder, in whom combined neoadjuvant chemotherapy with surgical intervention was effective in disease control and preserving urinary function. Case Presentation. Before neoadjuvant chemotherapy, all three cases underwent loop transverse colostomy for symptomatic colonic obstruction. Case 1: after 6 courses of capecitabine plus oxaliplatin (CAPOX), we performed sigmoid colectomy and partial resection of the bladder. The histological examination revealed pathological complete response (pCR). The final diagnosis was ypStage 0 (ypT0ypN0M0). Case 2: after 13 courses of CAPOX plus bevacizumab, we performed Hartmann’s operation with partial resection of the bladder. The histological examination revealed pCR. The final diagnosis was ypStage 0 (ypT0ypN0M0). Case 3: after 6 courses of chemotherapy with CAPOX plus bevacizumab, we performed sigmoid colectomy and partial resection of the bladder. The pathological response was grade 1a according to the Japanese Classification of Colorectal Carcinoma. The final diagnosis was ypStage IIC (ypT4bypN0M0). All three cases underwent capecitabine-based adjuvant chemotherapy after radical surgery and patients are alive without recurrence. Conclusion. Neoadjuvant chemotherapy with CAPOX with or without bevacizumab followed by radical surgery could be an effective treatment option for LACC invading the urinary bladder.http://dx.doi.org/10.1155/2019/8129358 |
| spellingShingle | Tsutomu Takenami Shingo Tsujinaka Jun Takahashi Sawako Tamaki Ryo Maemoto Rintaro Fukuda Hideki Ishikawa Nao Kakizawa Fumi Hasegawa Rina Kikugawa Yasuyuki Miyakura Koichi Suzuki Akira Tanaka Toshiki Rikiyama Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases Case Reports in Surgery |
| title | Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases |
| title_full | Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases |
| title_fullStr | Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases |
| title_full_unstemmed | Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases |
| title_short | Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases |
| title_sort | efficacy of neoadjuvant chemotherapy with capecitabine plus oxaliplatin in the treatment of locally advanced sigmoid colon cancer invading the urinary bladder a report of three cases |
| url | http://dx.doi.org/10.1155/2019/8129358 |
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