A new IDH-independent hypermethylation phenotype is associated with astrocyte-like cell state in glioblastoma
Abstract Background DNA methylation plays a crucial role in cancer development and progression and has been linked to genetically and clinically distinct tumor classes, including IDH-mutated and IDH-wildtype adult-type diffuse gliomas. Here, we identify a CpG-island methylator phenotype (CIMP) that...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-025-03670-y |
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