Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release
<b>Background/Objectives:</b> Focused ultrasound has advantages as an external stimulus for drug delivery as it is non-invasive, has high precision and can penetrate deep into tissues. Here, we report a gold-plated alginate (ALG) hydrogel system that retains highly water-soluble small-mo...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/1/133 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587701757411328 |
|---|---|
| author | Marcus Flowers Alex Paulsen Claire R. W. Kaiser Adam B. Tuma Hubert H. Lim Brenda M. Ogle Chun Wang |
| author_facet | Marcus Flowers Alex Paulsen Claire R. W. Kaiser Adam B. Tuma Hubert H. Lim Brenda M. Ogle Chun Wang |
| author_sort | Marcus Flowers |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Focused ultrasound has advantages as an external stimulus for drug delivery as it is non-invasive, has high precision and can penetrate deep into tissues. Here, we report a gold-plated alginate (ALG) hydrogel system that retains highly water-soluble small-molecule fluorescein for sharp off/on release after ultrasound exposure. <b>Methods:</b> The ALG is crosslinked into beads with calcium chloride and layered with a polycation to adjust the surface charge for the adsorption of catalytic platinum nanoparticles (Pt NPs). The coated bead is subject to electroless plating, forming a gold shell. Ultrasound is applied to the gold-plated ALG beads and the release of fluorescein with or without ultrasound stimulation is quantified. <b>Results:</b> Polyethylenimine (PEI), not poly-L-lysine (PLL), is able to facilitate Pt NP adsorption. Gold shell thickness is proportional to the duration of electroless plating and can be controlled. Gold-plated ALG beads are impermeable to the fluorescein cargo and have nearly zero leakage. Exposure to focused ultrasound initiated the release of fluorescein with full release achieved after 72 h. <b>Conclusions:</b> The gold-plated ALG hydrogel is a new material platform that can retain highly water-soluble molecules with a sharp off/on release initiated by focused ultrasound. |
| format | Article |
| id | doaj-art-342e733ace194897b4f7b1149a1a65ef |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-342e733ace194897b4f7b1149a1a65ef2025-01-24T13:46:05ZengMDPI AGPharmaceutics1999-49232025-01-0117113310.3390/pharmaceutics17010133Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered ReleaseMarcus Flowers0Alex Paulsen1Claire R. W. Kaiser2Adam B. Tuma3Hubert H. Lim4Brenda M. Ogle5Chun Wang6Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, USADepartment of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, USADepartment of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, USADepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Phillips Wangensteen Building, 516 Delaware Street SE, Suite 8-240, Minneapolis, MN 55455, USADepartment of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, USADepartment of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, USADepartment of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, USA<b>Background/Objectives:</b> Focused ultrasound has advantages as an external stimulus for drug delivery as it is non-invasive, has high precision and can penetrate deep into tissues. Here, we report a gold-plated alginate (ALG) hydrogel system that retains highly water-soluble small-molecule fluorescein for sharp off/on release after ultrasound exposure. <b>Methods:</b> The ALG is crosslinked into beads with calcium chloride and layered with a polycation to adjust the surface charge for the adsorption of catalytic platinum nanoparticles (Pt NPs). The coated bead is subject to electroless plating, forming a gold shell. Ultrasound is applied to the gold-plated ALG beads and the release of fluorescein with or without ultrasound stimulation is quantified. <b>Results:</b> Polyethylenimine (PEI), not poly-L-lysine (PLL), is able to facilitate Pt NP adsorption. Gold shell thickness is proportional to the duration of electroless plating and can be controlled. Gold-plated ALG beads are impermeable to the fluorescein cargo and have nearly zero leakage. Exposure to focused ultrasound initiated the release of fluorescein with full release achieved after 72 h. <b>Conclusions:</b> The gold-plated ALG hydrogel is a new material platform that can retain highly water-soluble molecules with a sharp off/on release initiated by focused ultrasound.https://www.mdpi.com/1999-4923/17/1/133triggered releaseultrasoundhydrogelalginategold |
| spellingShingle | Marcus Flowers Alex Paulsen Claire R. W. Kaiser Adam B. Tuma Hubert H. Lim Brenda M. Ogle Chun Wang Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release Pharmaceutics triggered release ultrasound hydrogel alginate gold |
| title | Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release |
| title_full | Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release |
| title_fullStr | Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release |
| title_full_unstemmed | Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release |
| title_short | Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release |
| title_sort | alginate hydrogel beads with a leakproof gold shell for ultrasound triggered release |
| topic | triggered release ultrasound hydrogel alginate gold |
| url | https://www.mdpi.com/1999-4923/17/1/133 |
| work_keys_str_mv | AT marcusflowers alginatehydrogelbeadswithaleakproofgoldshellforultrasoundtriggeredrelease AT alexpaulsen alginatehydrogelbeadswithaleakproofgoldshellforultrasoundtriggeredrelease AT clairerwkaiser alginatehydrogelbeadswithaleakproofgoldshellforultrasoundtriggeredrelease AT adambtuma alginatehydrogelbeadswithaleakproofgoldshellforultrasoundtriggeredrelease AT huberthlim alginatehydrogelbeadswithaleakproofgoldshellforultrasoundtriggeredrelease AT brendamogle alginatehydrogelbeadswithaleakproofgoldshellforultrasoundtriggeredrelease AT chunwang alginatehydrogelbeadswithaleakproofgoldshellforultrasoundtriggeredrelease |