Therapeutic efficacy of intra-articular injection of human adipose-derived mesenchymal stem cells in a sheep model of knee osteoarthritis

Therapeutic efficacy of intra-articular injection of human adipose-derived mesenchymal stem cells in a sheep model of knee osteoarthritis

Abstract Background Mesenchymal stem cells have great potential for repairing articular cartilage and treating knee osteoarthritis (KOA). Nonetheless, little is known about the efficacy of human adipose-derived mesenchymal stem cells (haMSCs) for KOA in large animal models. Methods This study evalua...

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Bibliographic Details
Main Authors: Jigang Lei, Xingyi Chen, Haohao Xie, Yuhao Dai, Zhongjin Chen, Liang Xu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Knee osteoarthritis
Cartilage
Magnetic resonance imaging
Intra-articular injection
Online Access:https://doi.org/10.1186/s13287-025-04143-6
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