Recent Progress of Genome Study for Anaplastic Thyroid Cancer
Anaplastic thyroid cancer (ATC) belongs to the most malignant and rapidly progressive human thyroid cancers and its prognosis is very poor. Also, it shows high resistance to cancer treatments, so that effective treatment for ATC has not been found to date, and virtually all patients terminate their...
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BioMed Central
2013-06-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-11-68.pdf |
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| _version_ | 1832573817116950528 |
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| author | Jieun Lee Jung-Ah Hwang Eun Kyung Lee |
| author_facet | Jieun Lee Jung-Ah Hwang Eun Kyung Lee |
| author_sort | Jieun Lee |
| collection | DOAJ |
| description | Anaplastic thyroid cancer (ATC) belongs to the most malignant and rapidly progressive human thyroid cancers and its prognosis is very poor. Also, it shows high resistance to cancer treatments, so that effective treatment for ATC has not been found to date, and virtually all patients terminate their life rapidly after diagnosis. Although targeted treatment of genetic alterations has emerged as an extremely promising approach to human cancers, such as BRAF in metastatic melanoma, it remains unclear that how commonly genomic alterations are influenced in ATC tumorigenesis. In recent years, genome wide approaches have been exploited to find genetic alterations associated with complex diseases, including cancer. Here, we reviewed the comprehensive genetic alterations in ATC and recent approaches in the context of identifying genomic alterations associated with ATC. Since surprisingly few reports have been published on the genome wide study of ATC, this review puts emphasis on the urgent needs of genomic research for the prevention and treatment of ATC. |
| format | Article |
| id | doaj-art-3427397909be4ab69b9ca9aea8853fea |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-06-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-3427397909be4ab69b9ca9aea8853fea2025-02-02T02:36:59ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-06-01112687510.5808/GI.2013.11.2.6883Recent Progress of Genome Study for Anaplastic Thyroid CancerJieun Lee0Jung-Ah Hwang1Eun Kyung Lee2Cancer Genomics Branch, Research Institute, National Cancer Center, Goyang 410-769, Korea.Cancer Genomics Branch, Research Institute, National Cancer Center, Goyang 410-769, Korea.Center for Thyroid Cancer, National Cancer Center, Goyang 410-769, Korea.Anaplastic thyroid cancer (ATC) belongs to the most malignant and rapidly progressive human thyroid cancers and its prognosis is very poor. Also, it shows high resistance to cancer treatments, so that effective treatment for ATC has not been found to date, and virtually all patients terminate their life rapidly after diagnosis. Although targeted treatment of genetic alterations has emerged as an extremely promising approach to human cancers, such as BRAF in metastatic melanoma, it remains unclear that how commonly genomic alterations are influenced in ATC tumorigenesis. In recent years, genome wide approaches have been exploited to find genetic alterations associated with complex diseases, including cancer. Here, we reviewed the comprehensive genetic alterations in ATC and recent approaches in the context of identifying genomic alterations associated with ATC. Since surprisingly few reports have been published on the genome wide study of ATC, this review puts emphasis on the urgent needs of genomic research for the prevention and treatment of ATC.http://genominfo.org/upload/pdf/gni-11-68.pdfanaplastic thyroid cancerdisease associated alterationsgenetic variation |
| spellingShingle | Jieun Lee Jung-Ah Hwang Eun Kyung Lee Recent Progress of Genome Study for Anaplastic Thyroid Cancer Genomics & Informatics anaplastic thyroid cancer disease associated alterations genetic variation |
| title | Recent Progress of Genome Study for Anaplastic Thyroid Cancer |
| title_full | Recent Progress of Genome Study for Anaplastic Thyroid Cancer |
| title_fullStr | Recent Progress of Genome Study for Anaplastic Thyroid Cancer |
| title_full_unstemmed | Recent Progress of Genome Study for Anaplastic Thyroid Cancer |
| title_short | Recent Progress of Genome Study for Anaplastic Thyroid Cancer |
| title_sort | recent progress of genome study for anaplastic thyroid cancer |
| topic | anaplastic thyroid cancer disease associated alterations genetic variation |
| url | http://genominfo.org/upload/pdf/gni-11-68.pdf |
| work_keys_str_mv | AT jieunlee recentprogressofgenomestudyforanaplasticthyroidcancer AT jungahhwang recentprogressofgenomestudyforanaplasticthyroidcancer AT eunkyunglee recentprogressofgenomestudyforanaplasticthyroidcancer |