Kawasaki Disease: A Clinician’s Update
Aims. Kawasaki disease is an acute systemic vasculitis and is the most common cause of acquired heart disease in children in the developed world. This review aims to synthesise recent insights into the disease and provide an update for clinicians on diagnostic and treatment practices. Methods. We c...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2013/645391 |
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| author | Nathan Jamieson Davinder Singh-Grewal |
| author_facet | Nathan Jamieson Davinder Singh-Grewal |
| author_sort | Nathan Jamieson |
| collection | DOAJ |
| description | Aims. Kawasaki disease is an acute systemic vasculitis and is the most common cause of acquired heart disease in children in the developed world. This review aims to synthesise recent insights into the disease and provide an update for clinicians on diagnostic and treatment practices.
Methods. We conducted a review of the literature exploring epidemiology, aetiology, diagnosis, and management of Kawasaki disease. We searched MEDLINE, Medline In-Process, Embase, Google Scholar, and reference lists of relevant articles. Conclusions. Kawasaki disease is a febrile vasculitis which progresses to coronary artery abnormalities in 25% of untreated patients. The disease is believed to result from a genetically susceptible individual’s exposure to an environmental trigger. Incidence is rising worldwide, and varies widely across countries and within different ethnic groups. Diagnosis is based on the presence of fever in addition to four out of five other clinical criteria, but it is complicated by the quarter of the Kawasaki disease patients with “incomplete” presentation. Treatment with intravenous immunoglobulin within ten days of fever onset improves clinical outcomes and reduces the incidence of coronary artery dilation to less than 5%. Given its severe morbidity and potential mortality, Kawasaki disease should be considered as a potential diagnosis in cases of prolonged paediatric fever. |
| format | Article |
| id | doaj-art-3417b0fcd95c422684ae36baf9a9567e |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-3417b0fcd95c422684ae36baf9a9567e2025-02-03T01:32:02ZengWileyInternational Journal of Pediatrics1687-97401687-97592013-01-01201310.1155/2013/645391645391Kawasaki Disease: A Clinician’s UpdateNathan Jamieson0Davinder Singh-Grewal1School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW 2052, AustraliaThe Sydney Children’s Hospitals Network, Randwick and Westmead Campuses, Sydney, NSW, AustraliaAims. Kawasaki disease is an acute systemic vasculitis and is the most common cause of acquired heart disease in children in the developed world. This review aims to synthesise recent insights into the disease and provide an update for clinicians on diagnostic and treatment practices. Methods. We conducted a review of the literature exploring epidemiology, aetiology, diagnosis, and management of Kawasaki disease. We searched MEDLINE, Medline In-Process, Embase, Google Scholar, and reference lists of relevant articles. Conclusions. Kawasaki disease is a febrile vasculitis which progresses to coronary artery abnormalities in 25% of untreated patients. The disease is believed to result from a genetically susceptible individual’s exposure to an environmental trigger. Incidence is rising worldwide, and varies widely across countries and within different ethnic groups. Diagnosis is based on the presence of fever in addition to four out of five other clinical criteria, but it is complicated by the quarter of the Kawasaki disease patients with “incomplete” presentation. Treatment with intravenous immunoglobulin within ten days of fever onset improves clinical outcomes and reduces the incidence of coronary artery dilation to less than 5%. Given its severe morbidity and potential mortality, Kawasaki disease should be considered as a potential diagnosis in cases of prolonged paediatric fever.http://dx.doi.org/10.1155/2013/645391 |
| spellingShingle | Nathan Jamieson Davinder Singh-Grewal Kawasaki Disease: A Clinician’s Update International Journal of Pediatrics |
| title | Kawasaki Disease: A Clinician’s Update |
| title_full | Kawasaki Disease: A Clinician’s Update |
| title_fullStr | Kawasaki Disease: A Clinician’s Update |
| title_full_unstemmed | Kawasaki Disease: A Clinician’s Update |
| title_short | Kawasaki Disease: A Clinician’s Update |
| title_sort | kawasaki disease a clinician s update |
| url | http://dx.doi.org/10.1155/2013/645391 |
| work_keys_str_mv | AT nathanjamieson kawasakidiseaseacliniciansupdate AT davindersinghgrewal kawasakidiseaseacliniciansupdate |