A Comparison between Enriched and Nonenriched Enrollment Randomized Withdrawal Trials of Opioids for Chronic Noncancer Pain
An enriched enrollment randomized withdrawal (EERW) trial design has been advocated to be useful for the study of drugs that are beneficial to only a fraction of the individuals who take them. Some investigators defend the use of enrichment designs for opioids in chronic noncancer pain (CNCP), reaso...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2011/465281 |
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| _version_ | 1832552147726630912 |
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| author | Andrea D Furlan Luis E Chaparro Emma Irvin Angela Mailis-Gagnon |
| author_facet | Andrea D Furlan Luis E Chaparro Emma Irvin Angela Mailis-Gagnon |
| author_sort | Andrea D Furlan |
| collection | DOAJ |
| description | An enriched enrollment randomized withdrawal (EERW) trial design has been advocated to be useful for the study of drugs that are beneficial to only a fraction of the individuals who take them. Some investigators defend the use of enrichment designs for opioids in chronic noncancer pain (CNCP), reasoning that opioids may appear to underperform in clinically heterogeneous contexts, ie, that substantial efficacy in a particular patient subgroup may be diluted or masked by poor efficacy in another subgroup. The authors previously published a systematic review of opioids for CNCP in 2006; however, at that time, there were only a few EERW trials available for comparison. This more exhaustive, updated review compares the results between EERW and non-EERW trials of opioids for a variety of CNCP conditions. |
| format | Article |
| id | doaj-art-3410994161134ffb8c4613f84898949c |
| institution | Kabale University |
| issn | 1203-6765 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-3410994161134ffb8c4613f84898949c2025-02-03T05:59:28ZengWileyPain Research and Management1203-67652011-01-0116533735110.1155/2011/465281A Comparison between Enriched and Nonenriched Enrollment Randomized Withdrawal Trials of Opioids for Chronic Noncancer PainAndrea D Furlan0Luis E Chaparro1Emma Irvin2Angela Mailis-Gagnon3Institute for Work & Health, University of Toronto, CanadaComprehensive Pain Program, Toronto Western Hospital, Toronto, Ontario, CanadaInstitute for Work & Health, University of Toronto, CanadaDivision of Physiatry, Department of Medicine, University of Toronto, CanadaAn enriched enrollment randomized withdrawal (EERW) trial design has been advocated to be useful for the study of drugs that are beneficial to only a fraction of the individuals who take them. Some investigators defend the use of enrichment designs for opioids in chronic noncancer pain (CNCP), reasoning that opioids may appear to underperform in clinically heterogeneous contexts, ie, that substantial efficacy in a particular patient subgroup may be diluted or masked by poor efficacy in another subgroup. The authors previously published a systematic review of opioids for CNCP in 2006; however, at that time, there were only a few EERW trials available for comparison. This more exhaustive, updated review compares the results between EERW and non-EERW trials of opioids for a variety of CNCP conditions.http://dx.doi.org/10.1155/2011/465281 |
| spellingShingle | Andrea D Furlan Luis E Chaparro Emma Irvin Angela Mailis-Gagnon A Comparison between Enriched and Nonenriched Enrollment Randomized Withdrawal Trials of Opioids for Chronic Noncancer Pain Pain Research and Management |
| title | A Comparison between Enriched and Nonenriched Enrollment Randomized Withdrawal Trials of Opioids for Chronic Noncancer Pain |
| title_full | A Comparison between Enriched and Nonenriched Enrollment Randomized Withdrawal Trials of Opioids for Chronic Noncancer Pain |
| title_fullStr | A Comparison between Enriched and Nonenriched Enrollment Randomized Withdrawal Trials of Opioids for Chronic Noncancer Pain |
| title_full_unstemmed | A Comparison between Enriched and Nonenriched Enrollment Randomized Withdrawal Trials of Opioids for Chronic Noncancer Pain |
| title_short | A Comparison between Enriched and Nonenriched Enrollment Randomized Withdrawal Trials of Opioids for Chronic Noncancer Pain |
| title_sort | comparison between enriched and nonenriched enrollment randomized withdrawal trials of opioids for chronic noncancer pain |
| url | http://dx.doi.org/10.1155/2011/465281 |
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