Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance
Insulin resistance and type 2 diabetes are associated with hepatitis C virus infection. A wealth of clinical and experimental data suggests that the virus is directly interfering with the insulin signalling in hepatocytes. In the case of at least one viral genotype (the type 3a), insulin resistance...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2009/483485 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555412415578112 |
|---|---|
| author | Francesco Negro |
| author_facet | Francesco Negro |
| author_sort | Francesco Negro |
| collection | DOAJ |
| description | Insulin resistance and type 2 diabetes are associated with hepatitis C virus infection. A wealth of clinical and experimental data suggests that the virus is directly interfering with the insulin signalling in hepatocytes. In the case of at least one viral genotype (the type 3a), insulin resistance seems to be directly mediated by the downregulation of the peroxisome proliferator-activated receptor γ. Whether and how this interaction may be manipulated pharmacologically, in order to improve the responsiveness to antivirals of insulin resistant chronic hepatitis C, patients remain to be fully explored. |
| format | Article |
| id | doaj-art-34041ded05aa4fe1990815b3fca25efe |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-34041ded05aa4fe1990815b3fca25efe2025-02-03T05:48:16ZengWileyPPAR Research1687-47571687-47652009-01-01200910.1155/2009/483485483485Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin ResistanceFrancesco Negro0Viropathology Unit, University of Geneva Medical Center, 1211 Geneva, SwitzerlandInsulin resistance and type 2 diabetes are associated with hepatitis C virus infection. A wealth of clinical and experimental data suggests that the virus is directly interfering with the insulin signalling in hepatocytes. In the case of at least one viral genotype (the type 3a), insulin resistance seems to be directly mediated by the downregulation of the peroxisome proliferator-activated receptor γ. Whether and how this interaction may be manipulated pharmacologically, in order to improve the responsiveness to antivirals of insulin resistant chronic hepatitis C, patients remain to be fully explored.http://dx.doi.org/10.1155/2009/483485 |
| spellingShingle | Francesco Negro Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance PPAR Research |
| title | Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance |
| title_full | Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance |
| title_fullStr | Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance |
| title_short | Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance |
| title_sort | peroxisome proliferator activated receptors and hepatitis c virus induced insulin resistance |
| url | http://dx.doi.org/10.1155/2009/483485 |
| work_keys_str_mv | AT francesconegro peroxisomeproliferatoractivatedreceptorsandhepatitiscvirusinducedinsulinresistance |