Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial
Lulan Li,1,* Liupan Zhang,1,2,* Xixuan Wu,1 Zhenhua Zeng1 1Department of Critical Care Medicine, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Internal Medicine, Zhongshan Shenwan Hospital,...
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Dove Medical Press
2025-01-01
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| author | Li L Zhang L Wu X Zeng Z |
| author_facet | Li L Zhang L Wu X Zeng Z |
| author_sort | Li L |
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| description | Lulan Li,1,* Liupan Zhang,1,2,* Xixuan Wu,1 Zhenhua Zeng1 1Department of Critical Care Medicine, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Internal Medicine, Zhongshan Shenwan Hospital, Zhongshan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenhua Zeng, Department of Critical Care Medicine, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Baiyun District, Guangzhou, 510515, People’s Republic of China, Tel/Fax +86 20 61641884, Email zhenhuazeng.2008@163.comBackground: Patients after head and neck tumor reconstruction surgery frequently require deep sedation and analgesia in the ICU. However, the risk factors for delirium associated with propofol-based sedation remain unclear.Objective: The study aimed to explore the risk factors of delirium of propofol singled or combined sedation.Methods: This retrospective study analyzed ICU patients who underwent head and neck tumor reconstruction surgery. The patients were divided into three groups: propofol (P), propofol + midazolam (PM), and propofol + dexmedetomidine (PD) groups. We utilized univariate and multivariate logistic regression to identify risk factors of delirium.Results: Delirium occurred in 4 (7.02%), 11 (28.21%), and 5 (20.83%) patients in the P, PM and PD groups, respectively. Elevated mean arterial pressure (MAP), increased aspartate aminotransferase (AST) levels, and the combined use of midazolam were determined to be significant risk factors for delirium in this patient cohort. The combined use of midazolam is the strongest predictor of delirium, which can increase the risk of delirium by 3.218 times (95% CI = 1.041– 9.950, p = 0.042).Conclusion: Propofol combined with midazolam for sedation in patients after head and neck tumor reconstruction surgery may increase the risk of delirium.Keywords: head and neck tumor reconstruction, delirium, propofol, midazolam, sedation, ICU |
| format | Article |
| id | doaj-art-3401b66b8bb64e42a8e165daa837d8ea |
| institution | Kabale University |
| issn | 1178-203X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
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| series | Therapeutics and Clinical Risk Management |
| spelling | doaj-art-3401b66b8bb64e42a8e165daa837d8ea2025-01-23T18:50:33ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2025-01-01Volume 21819199544Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical TrialLi LZhang LWu XZeng ZLulan Li,1,* Liupan Zhang,1,2,* Xixuan Wu,1 Zhenhua Zeng1 1Department of Critical Care Medicine, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Internal Medicine, Zhongshan Shenwan Hospital, Zhongshan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenhua Zeng, Department of Critical Care Medicine, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Baiyun District, Guangzhou, 510515, People’s Republic of China, Tel/Fax +86 20 61641884, Email zhenhuazeng.2008@163.comBackground: Patients after head and neck tumor reconstruction surgery frequently require deep sedation and analgesia in the ICU. However, the risk factors for delirium associated with propofol-based sedation remain unclear.Objective: The study aimed to explore the risk factors of delirium of propofol singled or combined sedation.Methods: This retrospective study analyzed ICU patients who underwent head and neck tumor reconstruction surgery. The patients were divided into three groups: propofol (P), propofol + midazolam (PM), and propofol + dexmedetomidine (PD) groups. We utilized univariate and multivariate logistic regression to identify risk factors of delirium.Results: Delirium occurred in 4 (7.02%), 11 (28.21%), and 5 (20.83%) patients in the P, PM and PD groups, respectively. Elevated mean arterial pressure (MAP), increased aspartate aminotransferase (AST) levels, and the combined use of midazolam were determined to be significant risk factors for delirium in this patient cohort. The combined use of midazolam is the strongest predictor of delirium, which can increase the risk of delirium by 3.218 times (95% CI = 1.041– 9.950, p = 0.042).Conclusion: Propofol combined with midazolam for sedation in patients after head and neck tumor reconstruction surgery may increase the risk of delirium.Keywords: head and neck tumor reconstruction, delirium, propofol, midazolam, sedation, ICUhttps://www.dovepress.com/risk-factors-of-delirium-following-reconstructive-surgery-for-head-and-peer-reviewed-fulltext-article-TCRMhead and neck tumor reconstructiondeliriumpropofolmidazolamsedationicu |
| spellingShingle | Li L Zhang L Wu X Zeng Z Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial Therapeutics and Clinical Risk Management head and neck tumor reconstruction delirium propofol midazolam sedation icu |
| title | Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial |
| title_full | Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial |
| title_fullStr | Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial |
| title_full_unstemmed | Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial |
| title_short | Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial |
| title_sort | risk factors of delirium following reconstructive surgery for head and neck tumors a retrospective clinical trial |
| topic | head and neck tumor reconstruction delirium propofol midazolam sedation icu |
| url | https://www.dovepress.com/risk-factors-of-delirium-following-reconstructive-surgery-for-head-and-peer-reviewed-fulltext-article-TCRM |
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