IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus
Polymorphisms in the cytokine genes and their natural antagonists are thought to influence the predisposition to dermatomyositis (DM) and systemic lupus erythematosus (SLE). A variable number tandem repeat (VNTR) polymorphism of 86 bp in intron 2 of the interleukin-1 receptor antagonist (IL-1RN) gen...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/953597 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556176713187328 |
|---|---|
| author | Zornitsa Kamenarska Gyulnas Dzhebir Maria Hristova Alexey Savov Anton Vinkov Radka Kaneva Vanio Mitev Lyubomir Dourmishev |
| author_facet | Zornitsa Kamenarska Gyulnas Dzhebir Maria Hristova Alexey Savov Anton Vinkov Radka Kaneva Vanio Mitev Lyubomir Dourmishev |
| author_sort | Zornitsa Kamenarska |
| collection | DOAJ |
| description | Polymorphisms in the cytokine genes and their natural antagonists are thought to influence the predisposition to dermatomyositis (DM) and systemic lupus erythematosus (SLE). A variable number tandem repeat (VNTR) polymorphism of 86 bp in intron 2 of the interleukin-1 receptor antagonist (IL-1RN) gene leads to the existence of five different alleles which cause differences in the production of both IL-1RA (interleukin-1 receptor antagonist) and IL-1β. The aim of this case-control study was to investigate the association between the IL-1RN VNTR polymorphism and the susceptibility to DM and SLE in Bulgarian patients. Altogether 91 patients, 55 with SLE and 36 with DM, as well as 112 unrelated healthy controls, were included in this study. Only three alleles were identified in both patients and controls ((1) four repeats, (2) two repeats, and (3) five repeats). The IL-1RN*2 allele (P=0.02, OR 2.5, and 95% CI 1.2–5.4) and the 1/2+2/2 genotypes were found prevalent among the SLE patients (P=0.05, OR 2.6, and 95% CI 1–6.3). No association was found between this polymorphism and the ACR criteria for SLE as well as with the susceptibility to DM. Our results indicate that the IL-1RN VNTR polymorphism might play a role in the susceptibility of SLE but not DM. |
| format | Article |
| id | doaj-art-33fb957b99c04e59906a5c173f84786d |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-33fb957b99c04e59906a5c173f84786d2025-02-03T05:46:10ZengWileyDermatology Research and Practice1687-61051687-61132014-01-01201410.1155/2014/953597953597IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus ErythematosusZornitsa Kamenarska0Gyulnas Dzhebir1Maria Hristova2Alexey Savov3Anton Vinkov4Radka Kaneva5Vanio Mitev6Lyubomir Dourmishev7Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaMolecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaDepartment of Clinical Laboratory and Clinical Immunology and Department of Nephrology, Medical University-Sofia, 1 Georgi Sofijski Street, 1431 Sofia, BulgariaNational Genetic Laboratory, Maichin Dom Hospital, 2 Zdrave Street, 1431 Sofia, Bulgaria28 Diagnostic and Consultative Center-Sofia, 1 Iliya Beshkov Street, 1592 Sofia, BulgariaMolecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaMolecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaDepartment of Dermatology and Venereology, Medical University-Sofia, 1 Georgi Sofijski Street, 1431 Sofia, BulgariaPolymorphisms in the cytokine genes and their natural antagonists are thought to influence the predisposition to dermatomyositis (DM) and systemic lupus erythematosus (SLE). A variable number tandem repeat (VNTR) polymorphism of 86 bp in intron 2 of the interleukin-1 receptor antagonist (IL-1RN) gene leads to the existence of five different alleles which cause differences in the production of both IL-1RA (interleukin-1 receptor antagonist) and IL-1β. The aim of this case-control study was to investigate the association between the IL-1RN VNTR polymorphism and the susceptibility to DM and SLE in Bulgarian patients. Altogether 91 patients, 55 with SLE and 36 with DM, as well as 112 unrelated healthy controls, were included in this study. Only three alleles were identified in both patients and controls ((1) four repeats, (2) two repeats, and (3) five repeats). The IL-1RN*2 allele (P=0.02, OR 2.5, and 95% CI 1.2–5.4) and the 1/2+2/2 genotypes were found prevalent among the SLE patients (P=0.05, OR 2.6, and 95% CI 1–6.3). No association was found between this polymorphism and the ACR criteria for SLE as well as with the susceptibility to DM. Our results indicate that the IL-1RN VNTR polymorphism might play a role in the susceptibility of SLE but not DM.http://dx.doi.org/10.1155/2014/953597 |
| spellingShingle | Zornitsa Kamenarska Gyulnas Dzhebir Maria Hristova Alexey Savov Anton Vinkov Radka Kaneva Vanio Mitev Lyubomir Dourmishev IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus Dermatology Research and Practice |
| title | IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus |
| title_full | IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus |
| title_fullStr | IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus |
| title_full_unstemmed | IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus |
| title_short | IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus |
| title_sort | il 1rn vntr polymorphism in adult dermatomyositis and systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2014/953597 |
| work_keys_str_mv | AT zornitsakamenarska il1rnvntrpolymorphisminadultdermatomyositisandsystemiclupuserythematosus AT gyulnasdzhebir il1rnvntrpolymorphisminadultdermatomyositisandsystemiclupuserythematosus AT mariahristova il1rnvntrpolymorphisminadultdermatomyositisandsystemiclupuserythematosus AT alexeysavov il1rnvntrpolymorphisminadultdermatomyositisandsystemiclupuserythematosus AT antonvinkov il1rnvntrpolymorphisminadultdermatomyositisandsystemiclupuserythematosus AT radkakaneva il1rnvntrpolymorphisminadultdermatomyositisandsystemiclupuserythematosus AT vaniomitev il1rnvntrpolymorphisminadultdermatomyositisandsystemiclupuserythematosus AT lyubomirdourmishev il1rnvntrpolymorphisminadultdermatomyositisandsystemiclupuserythematosus |