Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy
In the past few years, intensive research has focused on corneal stem cells as an unlimited source for cell-based therapy in regenerative ophthalmology. Today, it is known that the cornea has at least two types of stem cells: limbal epithelial stem cells (LESCs) and corneal stromal stem cells (CSSCs...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8813447 |
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| author | Jasmin S. Nurković Radiša Vojinović Zana Dolićanin |
| author_facet | Jasmin S. Nurković Radiša Vojinović Zana Dolićanin |
| author_sort | Jasmin S. Nurković |
| collection | DOAJ |
| description | In the past few years, intensive research has focused on corneal stem cells as an unlimited source for cell-based therapy in regenerative ophthalmology. Today, it is known that the cornea has at least two types of stem cells: limbal epithelial stem cells (LESCs) and corneal stromal stem cells (CSSCs). LESCs are used for regeneration of corneal surface, while CSSCs are used for regeneration of corneal stroma. Until now, various approaches and methods for isolation of LESCs and CSSCs and their successful transplantation have been described and tested in several preclinical studies and clinical trials. This review describes in detail phenotypic characteristics of LESCs and CSSCs and discusses their therapeutic potential in corneal regeneration. Since efficient and safe corneal stem cell-based therapy is still a challenging issue that requires continuous cooperation between researchers, clinicians, and patients, this review addresses the important limitations and suggests possible strategies for improvement of corneal stem cell-based therapy. |
| format | Article |
| id | doaj-art-33f6935dadcc4ffc869cd247677caf6b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-33f6935dadcc4ffc869cd247677caf6b2025-02-03T01:03:59ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88134478813447Corneal Stem Cells as a Source of Regenerative Cell-Based TherapyJasmin S. Nurković0Radiša Vojinović1Zana Dolićanin2Center for Regeneration and Rehabilitation, Novi Pazar, SerbiaFaculty of Medical Sciences, University of Kragujevac, Kragujevac, SerbiaDepartment of Biomedical Sciences, State University of Novi Pazar, Novi Pazar, SerbiaIn the past few years, intensive research has focused on corneal stem cells as an unlimited source for cell-based therapy in regenerative ophthalmology. Today, it is known that the cornea has at least two types of stem cells: limbal epithelial stem cells (LESCs) and corneal stromal stem cells (CSSCs). LESCs are used for regeneration of corneal surface, while CSSCs are used for regeneration of corneal stroma. Until now, various approaches and methods for isolation of LESCs and CSSCs and their successful transplantation have been described and tested in several preclinical studies and clinical trials. This review describes in detail phenotypic characteristics of LESCs and CSSCs and discusses their therapeutic potential in corneal regeneration. Since efficient and safe corneal stem cell-based therapy is still a challenging issue that requires continuous cooperation between researchers, clinicians, and patients, this review addresses the important limitations and suggests possible strategies for improvement of corneal stem cell-based therapy.http://dx.doi.org/10.1155/2020/8813447 |
| spellingShingle | Jasmin S. Nurković Radiša Vojinović Zana Dolićanin Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy Stem Cells International |
| title | Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy |
| title_full | Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy |
| title_fullStr | Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy |
| title_full_unstemmed | Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy |
| title_short | Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy |
| title_sort | corneal stem cells as a source of regenerative cell based therapy |
| url | http://dx.doi.org/10.1155/2020/8813447 |
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