The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells
Abstract Aedes mosquitoes transmit pathogenic arthropod-borne (arbo) viruses, putting nearly half the world’s population at risk. Blocking virus replication in mosquitoes is a promising approach to prevent arbovirus transmission, the development of which requires in-depth knowledge of virus-host int...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07435-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585413166891008 |
|---|---|
| author | Jieqiong Qu Michelle Schinkel Lisa Chiggiato Samara Rosendo Machado Gijs J. Overheul Pascal Miesen Ronald P. van Rij |
| author_facet | Jieqiong Qu Michelle Schinkel Lisa Chiggiato Samara Rosendo Machado Gijs J. Overheul Pascal Miesen Ronald P. van Rij |
| author_sort | Jieqiong Qu |
| collection | DOAJ |
| description | Abstract Aedes mosquitoes transmit pathogenic arthropod-borne (arbo) viruses, putting nearly half the world’s population at risk. Blocking virus replication in mosquitoes is a promising approach to prevent arbovirus transmission, the development of which requires in-depth knowledge of virus-host interactions and mosquito immunity. By integrating multi-omics data, we find that heat shock factor 1 (Hsf1) regulates eight small heat shock protein (sHsp) genes within one topologically associated domain in the genome of the Aedes aegypti mosquito. This Hsf1-sHsp cascade acts as an early response against chikungunya virus infection and shows pan-antiviral activity against chikungunya, Sindbis, and dengue virus as well as the insect-specific Agua Salud alphavirus in Ae. aegypti cells and against chikungunya virus and O’nyong-nyong virus in Aedes albopictus and Anopheles gambiae cells, respectively. Our comprehensive in vitro data suggest that Hsf1 could serve as a promising target for the development of novel intervention strategies to limit arbovirus transmission by mosquitoes. |
| format | Article |
| id | doaj-art-33f68967ee764bd2866ee5d771d44553 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-33f68967ee764bd2866ee5d771d445532025-01-26T12:48:22ZengNature PortfolioCommunications Biology2399-36422025-01-01811910.1038/s42003-024-07435-4The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cellsJieqiong Qu0Michelle Schinkel1Lisa Chiggiato2Samara Rosendo Machado3Gijs J. Overheul4Pascal Miesen5Ronald P. van Rij6Department of Medical Microbiology, Radboud University Medical CenterDepartment of Medical Microbiology, Radboud University Medical CenterDepartment of Medical Microbiology, Radboud University Medical CenterDepartment of Medical Microbiology, Radboud University Medical CenterDepartment of Medical Microbiology, Radboud University Medical CenterDepartment of Medical Microbiology, Radboud University Medical CenterDepartment of Medical Microbiology, Radboud University Medical CenterAbstract Aedes mosquitoes transmit pathogenic arthropod-borne (arbo) viruses, putting nearly half the world’s population at risk. Blocking virus replication in mosquitoes is a promising approach to prevent arbovirus transmission, the development of which requires in-depth knowledge of virus-host interactions and mosquito immunity. By integrating multi-omics data, we find that heat shock factor 1 (Hsf1) regulates eight small heat shock protein (sHsp) genes within one topologically associated domain in the genome of the Aedes aegypti mosquito. This Hsf1-sHsp cascade acts as an early response against chikungunya virus infection and shows pan-antiviral activity against chikungunya, Sindbis, and dengue virus as well as the insect-specific Agua Salud alphavirus in Ae. aegypti cells and against chikungunya virus and O’nyong-nyong virus in Aedes albopictus and Anopheles gambiae cells, respectively. Our comprehensive in vitro data suggest that Hsf1 could serve as a promising target for the development of novel intervention strategies to limit arbovirus transmission by mosquitoes.https://doi.org/10.1038/s42003-024-07435-4 |
| spellingShingle | Jieqiong Qu Michelle Schinkel Lisa Chiggiato Samara Rosendo Machado Gijs J. Overheul Pascal Miesen Ronald P. van Rij The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells Communications Biology |
| title | The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells |
| title_full | The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells |
| title_fullStr | The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells |
| title_full_unstemmed | The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells |
| title_short | The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells |
| title_sort | hsf1 shsp cascade has pan antiviral activity in mosquito cells |
| url | https://doi.org/10.1038/s42003-024-07435-4 |
| work_keys_str_mv | AT jieqiongqu thehsf1shspcascadehaspanantiviralactivityinmosquitocells AT michelleschinkel thehsf1shspcascadehaspanantiviralactivityinmosquitocells AT lisachiggiato thehsf1shspcascadehaspanantiviralactivityinmosquitocells AT samararosendomachado thehsf1shspcascadehaspanantiviralactivityinmosquitocells AT gijsjoverheul thehsf1shspcascadehaspanantiviralactivityinmosquitocells AT pascalmiesen thehsf1shspcascadehaspanantiviralactivityinmosquitocells AT ronaldpvanrij thehsf1shspcascadehaspanantiviralactivityinmosquitocells AT jieqiongqu hsf1shspcascadehaspanantiviralactivityinmosquitocells AT michelleschinkel hsf1shspcascadehaspanantiviralactivityinmosquitocells AT lisachiggiato hsf1shspcascadehaspanantiviralactivityinmosquitocells AT samararosendomachado hsf1shspcascadehaspanantiviralactivityinmosquitocells AT gijsjoverheul hsf1shspcascadehaspanantiviralactivityinmosquitocells AT pascalmiesen hsf1shspcascadehaspanantiviralactivityinmosquitocells AT ronaldpvanrij hsf1shspcascadehaspanantiviralactivityinmosquitocells |