USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells

USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells

Ubiquitin specific protease-14 (USP14) is critical for controlling proteostasis disturbed in human disorders, including Parkinson's disease (PD). Here we investigated USP14 in the regulation of α-synuclein (α-syn) degradation via the proteasome and autophagy. α-Syn and pS129 α-syn were elevated...

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Bibliographic Details
Main Authors: Vignesh Srinivasan, Rabah Soliymani, Larisa Ivanova, Ove Eriksson, Nina Peitsaro, Maciej Lalowski, Mati Karelson, Dan Lindholm
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
USP14
Proteasome
α-Synuclein
pS129 α-Synuclein
Oxidative stress
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025004116
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