Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization
Allergic rhinitis (AR) is especially prevalent among the population of large cities. Immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. These cells actively express a group of receptors of the innate immune system. A specific cytokine p...
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| Format: | Article |
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2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3054217 |
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| author | Yury A. Tyurin Svetlana A. Lissovskaya Rustem S. Fassahov Ilshat G. Mustafin Anton F. Shamsutdinov Marina A. Shilova Albert A. Rizvanov |
| author_facet | Yury A. Tyurin Svetlana A. Lissovskaya Rustem S. Fassahov Ilshat G. Mustafin Anton F. Shamsutdinov Marina A. Shilova Albert A. Rizvanov |
| author_sort | Yury A. Tyurin |
| collection | DOAJ |
| description | Allergic rhinitis (AR) is especially prevalent among the population of large cities. Immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. These cells actively express a group of receptors of the innate immune system. A specific cytokine profile is its representation. The study was aimed at evaluating the cytokine profile in patients with seasonal and perennial allergic rhinitis. The cytokine profile of nasal secretion and blood serum of 44 patients with AR was studied. 24 of them had seasonal allergic rhinitis (SAR), and 20 patients suffered from perennial allergic rhinitis (PAR). The patients’ age ranged from 4 to 60 years. It was determined in our study that the activation of the GM-CSF production retained in patients with PAR sensitized to mite allergen components (Dermatophagoides pteronyssinus). There was a higher production profile of TNF-α and TSLP in nasal secretion in the patients with perennial allergic rhinitis and additional high sensitization to SEs. Sensitization to mold fungal allergen components significantly increases in patients with seasonal allergic rhinitis. They demonstrated high level of sensitization to the Aspergillus fumigatus component m3. Thus, along with other clinical trials, the study performed would clarify some aspects of molecular pathogenesis of human allergic rhinitis. |
| format | Article |
| id | doaj-art-33f3e14e589a4415aba9ff5983cbda46 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-33f3e14e589a4415aba9ff5983cbda462025-02-03T06:01:21ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/30542173054217Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen SensitizationYury A. Tyurin0Svetlana A. Lissovskaya1Rustem S. Fassahov2Ilshat G. Mustafin3Anton F. Shamsutdinov4Marina A. Shilova5Albert A. Rizvanov6Department of Biochemistry and Clinical Laboratory Diagnostics, Medical State University, Butlerov Street 49, Kazan, Republic of Tatarstan, RussiaLaboratory of Immunology and the Development of Allergens, Mycology Research Laboratory, Research Institute of Epidemiology and Microbiology, Big Red Street 67, Kazan, Republic of Tatarstan 420015, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008, RussiaDepartment of Biochemistry and Clinical Laboratory Diagnostics, Medical State University, Butlerov Street 49, Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008, RussiaI.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya Str., Moscow 119991, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008, RussiaAllergic rhinitis (AR) is especially prevalent among the population of large cities. Immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. These cells actively express a group of receptors of the innate immune system. A specific cytokine profile is its representation. The study was aimed at evaluating the cytokine profile in patients with seasonal and perennial allergic rhinitis. The cytokine profile of nasal secretion and blood serum of 44 patients with AR was studied. 24 of them had seasonal allergic rhinitis (SAR), and 20 patients suffered from perennial allergic rhinitis (PAR). The patients’ age ranged from 4 to 60 years. It was determined in our study that the activation of the GM-CSF production retained in patients with PAR sensitized to mite allergen components (Dermatophagoides pteronyssinus). There was a higher production profile of TNF-α and TSLP in nasal secretion in the patients with perennial allergic rhinitis and additional high sensitization to SEs. Sensitization to mold fungal allergen components significantly increases in patients with seasonal allergic rhinitis. They demonstrated high level of sensitization to the Aspergillus fumigatus component m3. Thus, along with other clinical trials, the study performed would clarify some aspects of molecular pathogenesis of human allergic rhinitis.http://dx.doi.org/10.1155/2017/3054217 |
| spellingShingle | Yury A. Tyurin Svetlana A. Lissovskaya Rustem S. Fassahov Ilshat G. Mustafin Anton F. Shamsutdinov Marina A. Shilova Albert A. Rizvanov Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization Journal of Immunology Research |
| title | Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization |
| title_full | Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization |
| title_fullStr | Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization |
| title_full_unstemmed | Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization |
| title_short | Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization |
| title_sort | cytokine profile of patients with allergic rhinitis caused by pollen mite and microbial allergen sensitization |
| url | http://dx.doi.org/10.1155/2017/3054217 |
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