New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy
Background. The diagnosis of acute myocarditis (AMC) and inflammatory cardiomyopathy (DCMi) can be difficult. Speckle tracking echocardiography with accurate assessments of regional contractility could have an outstanding importance for the diagnosis. Methods and Results. N=25 patients with clinical...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/875420 |
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| author | Felicitas Escher Mario Kasner Uwe Kühl Johannes Heymer Ursula Wilkenshoff Carsten Tschöpe Heinz-Peter Schultheiss |
| author_facet | Felicitas Escher Mario Kasner Uwe Kühl Johannes Heymer Ursula Wilkenshoff Carsten Tschöpe Heinz-Peter Schultheiss |
| author_sort | Felicitas Escher |
| collection | DOAJ |
| description | Background. The diagnosis of acute myocarditis (AMC) and inflammatory cardiomyopathy (DCMi) can be difficult. Speckle tracking echocardiography with accurate assessments of regional contractility could have an outstanding importance for the diagnosis. Methods and Results. N=25 patients with clinically diagnosed AMC who underwent endomyocardial biopsies (EMBs) were studied prospectively. Speckle tracking imaging was examined at the beginning and during a mean follow-up period of 6.2 months. In the acute phase patients had markedly decreased left ventricular (LV) systolic function (mean LV ejection fraction (LVEF) 40.4±10.3%). At follow-up in n=8 patients, inflammation persists, correlating with a significantly reduced fractional shortening (FS, 21.5±6.0%) in contrast to those without inflammation in EMB (FS 32.1±7.1%, P<0.05). All AMC patients showed a reduction in global systolic longitudinal strain (LS, −8.36±−3.47%) and strain rate (LSR, 0.53±0.29 1/s). At follow-up, LS and LRS were significantly lower in patients with inflammation, in contrast to patients without inflammation (−9.4±1.4 versus −16.8±2.0%, P<0.0001; 0.78±0.4 versus 1.3±0.3 1/s). LSR and LS correlate significantly with lymphocytic infiltrates (for CD3 r=0.7, P<0.0001, and LFA-1 r=0.8, P<0.0001). Conclusion. Speckle tracking echocardiography is a useful adjunctive assisting tool for evaluation over the course of intramyocardial inflammation in patients with AMC and DCMi. |
| format | Article |
| id | doaj-art-33f2ded92a0f4f1ab87fefec3e56c144 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-33f2ded92a0f4f1ab87fefec3e56c1442025-02-03T06:12:44ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/875420875420New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory CardiomyopathyFelicitas Escher0Mario Kasner1Uwe Kühl2Johannes Heymer3Ursula Wilkenshoff4Carsten Tschöpe5Heinz-Peter Schultheiss6Department of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, GermanyDepartment of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, GermanyDepartment of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, GermanyDepartment of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, GermanyDepartment of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, GermanyDepartment of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, GermanyDepartment of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, GermanyBackground. The diagnosis of acute myocarditis (AMC) and inflammatory cardiomyopathy (DCMi) can be difficult. Speckle tracking echocardiography with accurate assessments of regional contractility could have an outstanding importance for the diagnosis. Methods and Results. N=25 patients with clinically diagnosed AMC who underwent endomyocardial biopsies (EMBs) were studied prospectively. Speckle tracking imaging was examined at the beginning and during a mean follow-up period of 6.2 months. In the acute phase patients had markedly decreased left ventricular (LV) systolic function (mean LV ejection fraction (LVEF) 40.4±10.3%). At follow-up in n=8 patients, inflammation persists, correlating with a significantly reduced fractional shortening (FS, 21.5±6.0%) in contrast to those without inflammation in EMB (FS 32.1±7.1%, P<0.05). All AMC patients showed a reduction in global systolic longitudinal strain (LS, −8.36±−3.47%) and strain rate (LSR, 0.53±0.29 1/s). At follow-up, LS and LRS were significantly lower in patients with inflammation, in contrast to patients without inflammation (−9.4±1.4 versus −16.8±2.0%, P<0.0001; 0.78±0.4 versus 1.3±0.3 1/s). LSR and LS correlate significantly with lymphocytic infiltrates (for CD3 r=0.7, P<0.0001, and LFA-1 r=0.8, P<0.0001). Conclusion. Speckle tracking echocardiography is a useful adjunctive assisting tool for evaluation over the course of intramyocardial inflammation in patients with AMC and DCMi.http://dx.doi.org/10.1155/2013/875420 |
| spellingShingle | Felicitas Escher Mario Kasner Uwe Kühl Johannes Heymer Ursula Wilkenshoff Carsten Tschöpe Heinz-Peter Schultheiss New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy Mediators of Inflammation |
| title | New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy |
| title_full | New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy |
| title_fullStr | New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy |
| title_full_unstemmed | New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy |
| title_short | New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy |
| title_sort | new echocardiographic findings correlate with intramyocardial inflammation in endomyocardial biopsies of patients with acute myocarditis and inflammatory cardiomyopathy |
| url | http://dx.doi.org/10.1155/2013/875420 |
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