The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm
Despite the fundamental importance of muscle coordination in daily life, it is currently unclear how muscle coordination adapts when the musculoskeletal system is perturbed. In this study, we quantified the impact of selective muscle weakness on several metrics of muscle coordination. Seven healthy...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2018/5637568 |
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| author | Jinsook Roh Randall F. Beer Andrew Lai Monica Rho Kristopher R. Karvelas Antoun M. Nader Mark C. Kendall William Z. Rymer |
| author_facet | Jinsook Roh Randall F. Beer Andrew Lai Monica Rho Kristopher R. Karvelas Antoun M. Nader Mark C. Kendall William Z. Rymer |
| author_sort | Jinsook Roh |
| collection | DOAJ |
| description | Despite the fundamental importance of muscle coordination in daily life, it is currently unclear how muscle coordination adapts when the musculoskeletal system is perturbed. In this study, we quantified the impact of selective muscle weakness on several metrics of muscle coordination. Seven healthy subjects performed 2D and 3D isometric force target matches, while electromyographic (EMG) signals were recorded from 13 elbow and shoulder muscles. Subsequently, muscle weakness was induced by a motor point block of brachialis muscle. Postblock subjects repeated the force generation tasks. We quantified muscle coordination pre- and postblock using three metrics: tuning curve preferred direction, tuning curve area, and motor modules analysis via nonnegative matrix factorization. For most muscles, the tuning direction for the 2D protocol was not substantially altered postblock, while tuning areas changed more drastically. Typically, five motor modules were identified from the 3D task, and four motor modules were identified in the 2D task; this result held across both pre- and postblock conditions. The composition of one or two motor modules, ones that involved mainly the activation of shoulder muscles, was altered postblock. Our results demonstrate that selective muscle weakness can induce nonintuitive alternations in muscle coordination in the mechanically redundant human arm. |
| format | Article |
| id | doaj-art-33e7c2ac42424ffe90689e1b3dd3740a |
| institution | Kabale University |
| issn | 1176-2322 1754-2103 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-33e7c2ac42424ffe90689e1b3dd3740a2025-02-03T05:45:40ZengWileyApplied Bionics and Biomechanics1176-23221754-21032018-01-01201810.1155/2018/56375685637568The Effects of Selective Muscle Weakness on Muscle Coordination in the Human ArmJinsook Roh0Randall F. Beer1Andrew Lai2Monica Rho3Kristopher R. Karvelas4Antoun M. Nader5Mark C. Kendall6William Z. Rymer7Department of Kinesiology, Temple University, Philadelphia, PA 19122, USADepartment of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Biomedical Engineering, Northwestern University, Chicago, IL 60611, USADepartment of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Physical Medicine and Rehabilitation, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USADepartment of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Anesthesiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USADepartment of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADespite the fundamental importance of muscle coordination in daily life, it is currently unclear how muscle coordination adapts when the musculoskeletal system is perturbed. In this study, we quantified the impact of selective muscle weakness on several metrics of muscle coordination. Seven healthy subjects performed 2D and 3D isometric force target matches, while electromyographic (EMG) signals were recorded from 13 elbow and shoulder muscles. Subsequently, muscle weakness was induced by a motor point block of brachialis muscle. Postblock subjects repeated the force generation tasks. We quantified muscle coordination pre- and postblock using three metrics: tuning curve preferred direction, tuning curve area, and motor modules analysis via nonnegative matrix factorization. For most muscles, the tuning direction for the 2D protocol was not substantially altered postblock, while tuning areas changed more drastically. Typically, five motor modules were identified from the 3D task, and four motor modules were identified in the 2D task; this result held across both pre- and postblock conditions. The composition of one or two motor modules, ones that involved mainly the activation of shoulder muscles, was altered postblock. Our results demonstrate that selective muscle weakness can induce nonintuitive alternations in muscle coordination in the mechanically redundant human arm.http://dx.doi.org/10.1155/2018/5637568 |
| spellingShingle | Jinsook Roh Randall F. Beer Andrew Lai Monica Rho Kristopher R. Karvelas Antoun M. Nader Mark C. Kendall William Z. Rymer The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm Applied Bionics and Biomechanics |
| title | The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm |
| title_full | The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm |
| title_fullStr | The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm |
| title_full_unstemmed | The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm |
| title_short | The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm |
| title_sort | effects of selective muscle weakness on muscle coordination in the human arm |
| url | http://dx.doi.org/10.1155/2018/5637568 |
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