THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION
The transcriptional activity of genes was studied in kidneys of hypertensive ISIAH and normotensive WAG rats in order to detect genes significantly expressed in kidneys of just one of the analyzed strains. Gene profiling was performed on the Illumina RatRef-12 Expression BeadChip microarray platform...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-01-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/321 |
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| author | O. E. Redina L. O. Klimov N. I. Ershov T. O. Abramova L. N. Ivanova L. A. Markel |
| author_facet | O. E. Redina L. O. Klimov N. I. Ershov T. O. Abramova L. N. Ivanova L. A. Markel |
| author_sort | O. E. Redina |
| collection | DOAJ |
| description | The transcriptional activity of genes was studied in kidneys of hypertensive ISIAH and normotensive WAG rats in order to detect genes significantly expressed in kidneys of just one of the analyzed strains. Gene profiling was performed on the Illumina RatRef-12 Expression BeadChip microarray platform. The expression of three genes (Klk1, Klk1c10, and Kng1) related to the kallikrein-kinin system was significant in the WAG renal cortex but was not detected in hypertensive kidneys. The downregulation of these three genes and Gucy1a3 in ISIAH renal cortex suggests the weakened function of the kallikrein-kinin system in hypertensive kidneys, which may cause blood circulation disturbances in renal glomeruli and mediate the development of hypertension in ISIAH rats. The functional annotation of the genes significantly expressed in renal medulla of just one of the compared rat strains revealed the genes involved in immune response regulation. |
| format | Article |
| id | doaj-art-33e71f697df04aa38cc8da2aa9d5c506 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-33e71f697df04aa38cc8da2aa9d5c5062025-02-01T09:58:01ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-01-01184/2910919304THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSIONO. E. Redina0L. O. Klimov1N. I. Ershov2T. O. Abramova3L. N. Ivanova4L. A. Markel5Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaThe transcriptional activity of genes was studied in kidneys of hypertensive ISIAH and normotensive WAG rats in order to detect genes significantly expressed in kidneys of just one of the analyzed strains. Gene profiling was performed on the Illumina RatRef-12 Expression BeadChip microarray platform. The expression of three genes (Klk1, Klk1c10, and Kng1) related to the kallikrein-kinin system was significant in the WAG renal cortex but was not detected in hypertensive kidneys. The downregulation of these three genes and Gucy1a3 in ISIAH renal cortex suggests the weakened function of the kallikrein-kinin system in hypertensive kidneys, which may cause blood circulation disturbances in renal glomeruli and mediate the development of hypertension in ISIAH rats. The functional annotation of the genes significantly expressed in renal medulla of just one of the compared rat strains revealed the genes involved in immune response regulation.https://vavilov.elpub.ru/jour/article/view/321isiah ratstranscriptional activity of genesmicroarraysstress-induced arterial hypertensionemotional stress |
| spellingShingle | O. E. Redina L. O. Klimov N. I. Ershov T. O. Abramova L. N. Ivanova L. A. Markel THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION Вавиловский журнал генетики и селекции isiah rats transcriptional activity of genes microarrays stress-induced arterial hypertension emotional stress |
| title | THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION |
| title_full | THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION |
| title_fullStr | THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION |
| title_full_unstemmed | THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION |
| title_short | THE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION |
| title_sort | downregulation of genes controlling vascular tone in kidneys of isiah rats with stress induced arterial hypertension |
| topic | isiah rats transcriptional activity of genes microarrays stress-induced arterial hypertension emotional stress |
| url | https://vavilov.elpub.ru/jour/article/view/321 |
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