Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratification
Abstract Laparoscopic Sleeve Gastrectomy (LSG) is the most common bariatric procedure worldwide. However, the influence of preoperative factors on weight loss outcomes remains incompletely understood. We investigated the effects of preoperative weight, height, and age on total weight loss percentage...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-93826-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849773962110697472 |
|---|---|
| author | Burak Kankaya Suleyman Buyukasik Yusuf Emre Altundal Mustafa Ozgul Ayden Etemad Paria Rahmanbakhsh Esra Guzelaltuncekic Halil Alis |
| author_facet | Burak Kankaya Suleyman Buyukasik Yusuf Emre Altundal Mustafa Ozgul Ayden Etemad Paria Rahmanbakhsh Esra Guzelaltuncekic Halil Alis |
| author_sort | Burak Kankaya |
| collection | DOAJ |
| description | Abstract Laparoscopic Sleeve Gastrectomy (LSG) is the most common bariatric procedure worldwide. However, the influence of preoperative factors on weight loss outcomes remains incompletely understood. We investigated the effects of preoperative weight, height, and age on total weight loss percentage (%TWL) following LSG using advanced statistical modeling. 2014 LSG patients were analyzed and stratified by preoperative weight (7 categories: <90 kg to > 160 kg) and age (5 groups: 14–25 to ≥ 56 years). %TWL was calculated at 1 week, 1, 3, 6, and 12 months post-surgery. A Generalized Additive Model (GAM) was used to calculate Adjusted Total Weight Loss percentage (%ATWL), accounting for height and preoperative weight confounding effects. The population (mean age: 38.0 ± 11.4 years, BMI: 42.9 ± 8.2 kg/m²) showed weight-dependent %TWL at 12 months, from 32.2%±10.0% (< 90 kg) to 39.8%±7.5% (> 160 kg) (p < 0.001). GAM-adjusted %ATWL revealed superior outcomes in younger cohorts. The 14–25 and 26–35 year groups had comparable 12-month %ATWL (38.2% vs. 37.0%, p = 0.222), significantly exceeding older groups (p < 0.001). Early postoperative %ATWL (1-week) was similar across ages (4.6–5.7%), with progressive differentiation at 3, 6, and 12 months. Preoperative weight and age significantly influence LSG weight loss outcomes. Younger patients and those with higher pre-op weights achieved greater 12-month %TWL. |
| format | Article |
| id | doaj-art-33e69564c4d74de0a8cff843a3e36ebc |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-33e69564c4d74de0a8cff843a3e36ebc2025-08-20T03:01:54ZengNature PortfolioScientific Reports2045-23222025-03-0115111110.1038/s41598-025-93826-4Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratificationBurak Kankaya0Suleyman Buyukasik1Yusuf Emre Altundal2Mustafa Ozgul3Ayden Etemad4Paria Rahmanbakhsh5Esra Guzelaltuncekic6Halil Alis7Department of General Surgery, Faculty of Medicine, Istanbul Aydin UniversityDepartment of General Surgery, Faculty of Medicine, Istanbul Aydin UniversityDepartment of General Surgery, Faculty of Medicine, Istanbul Aydin UniversityDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California IrvineDepartment of General Surgery, Faculty of Medicine, Istanbul Aydin UniversityDepartment of General Surgery, Faculty of Medicine, Istanbul Aydin UniversityDepartment of General Surgery, Faculty of Medicine, Istanbul Aydin UniversityDepartment of General Surgery, Faculty of Medicine, Istanbul Aydin UniversityAbstract Laparoscopic Sleeve Gastrectomy (LSG) is the most common bariatric procedure worldwide. However, the influence of preoperative factors on weight loss outcomes remains incompletely understood. We investigated the effects of preoperative weight, height, and age on total weight loss percentage (%TWL) following LSG using advanced statistical modeling. 2014 LSG patients were analyzed and stratified by preoperative weight (7 categories: <90 kg to > 160 kg) and age (5 groups: 14–25 to ≥ 56 years). %TWL was calculated at 1 week, 1, 3, 6, and 12 months post-surgery. A Generalized Additive Model (GAM) was used to calculate Adjusted Total Weight Loss percentage (%ATWL), accounting for height and preoperative weight confounding effects. The population (mean age: 38.0 ± 11.4 years, BMI: 42.9 ± 8.2 kg/m²) showed weight-dependent %TWL at 12 months, from 32.2%±10.0% (< 90 kg) to 39.8%±7.5% (> 160 kg) (p < 0.001). GAM-adjusted %ATWL revealed superior outcomes in younger cohorts. The 14–25 and 26–35 year groups had comparable 12-month %ATWL (38.2% vs. 37.0%, p = 0.222), significantly exceeding older groups (p < 0.001). Early postoperative %ATWL (1-week) was similar across ages (4.6–5.7%), with progressive differentiation at 3, 6, and 12 months. Preoperative weight and age significantly influence LSG weight loss outcomes. Younger patients and those with higher pre-op weights achieved greater 12-month %TWL.https://doi.org/10.1038/s41598-025-93826-4Laparoscopic sleeve gastrectomyWeight loss outcomesAge-stratified outcomesPreoperative weightGeneralized additive model |
| spellingShingle | Burak Kankaya Suleyman Buyukasik Yusuf Emre Altundal Mustafa Ozgul Ayden Etemad Paria Rahmanbakhsh Esra Guzelaltuncekic Halil Alis Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratification Scientific Reports Laparoscopic sleeve gastrectomy Weight loss outcomes Age-stratified outcomes Preoperative weight Generalized additive model |
| title | Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratification |
| title_full | Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratification |
| title_fullStr | Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratification |
| title_full_unstemmed | Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratification |
| title_short | Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratification |
| title_sort | weight loss dynamics after laparoscopic sleeve gastrectomy a retrospective single center analysis with age and preoperative weight stratification |
| topic | Laparoscopic sleeve gastrectomy Weight loss outcomes Age-stratified outcomes Preoperative weight Generalized additive model |
| url | https://doi.org/10.1038/s41598-025-93826-4 |
| work_keys_str_mv | AT burakkankaya weightlossdynamicsafterlaparoscopicsleevegastrectomyaretrospectivesinglecenteranalysiswithageandpreoperativeweightstratification AT suleymanbuyukasik weightlossdynamicsafterlaparoscopicsleevegastrectomyaretrospectivesinglecenteranalysiswithageandpreoperativeweightstratification AT yusufemrealtundal weightlossdynamicsafterlaparoscopicsleevegastrectomyaretrospectivesinglecenteranalysiswithageandpreoperativeweightstratification AT mustafaozgul weightlossdynamicsafterlaparoscopicsleevegastrectomyaretrospectivesinglecenteranalysiswithageandpreoperativeweightstratification AT aydenetemad weightlossdynamicsafterlaparoscopicsleevegastrectomyaretrospectivesinglecenteranalysiswithageandpreoperativeweightstratification AT pariarahmanbakhsh weightlossdynamicsafterlaparoscopicsleevegastrectomyaretrospectivesinglecenteranalysiswithageandpreoperativeweightstratification AT esraguzelaltuncekic weightlossdynamicsafterlaparoscopicsleevegastrectomyaretrospectivesinglecenteranalysiswithageandpreoperativeweightstratification AT halilalis weightlossdynamicsafterlaparoscopicsleevegastrectomyaretrospectivesinglecenteranalysiswithageandpreoperativeweightstratification |