The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches
The recruitment of neutrophil to the primary cancer has been shown to be steered by neoplastic cells or tumor-educated mesenchymal stromal cells and has a prometastatic effect. However, the neutrophil chemotaxis and their interaction with tumor cells in the distal metastasized tissues remain elusive...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6687474 |
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| _version_ | 1832547694084620288 |
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| author | Xin Xing Yongrui Bai Jian Song |
| author_facet | Xin Xing Yongrui Bai Jian Song |
| author_sort | Xin Xing |
| collection | DOAJ |
| description | The recruitment of neutrophil to the primary cancer has been shown to be steered by neoplastic cells or tumor-educated mesenchymal stromal cells and has a prometastatic effect. However, the neutrophil chemotaxis and their interaction with tumor cells in the distal metastasized tissues remain elusive. In this review, we discussed emerging research on the interaction between neutrophil recruitment and tumor metastasis, which is essential for studying tumor cell invasion and related immunotherapy. |
| format | Article |
| id | doaj-art-33e2deeeb39a4ad3a54893b026fb17e0 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-33e2deeeb39a4ad3a54893b026fb17e02025-02-03T06:43:47ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/66874746687474The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic NichesXin Xing0Yongrui Bai1Jian Song2Shanghai Fengxian District Central Hospital, No. 6600, Nanfeng Road, Shanghai, 201499, ChinaDepartment of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, ChinaDepartment of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, ChinaThe recruitment of neutrophil to the primary cancer has been shown to be steered by neoplastic cells or tumor-educated mesenchymal stromal cells and has a prometastatic effect. However, the neutrophil chemotaxis and their interaction with tumor cells in the distal metastasized tissues remain elusive. In this review, we discussed emerging research on the interaction between neutrophil recruitment and tumor metastasis, which is essential for studying tumor cell invasion and related immunotherapy.http://dx.doi.org/10.1155/2021/6687474 |
| spellingShingle | Xin Xing Yongrui Bai Jian Song The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches Journal of Immunology Research |
| title | The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches |
| title_full | The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches |
| title_fullStr | The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches |
| title_full_unstemmed | The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches |
| title_short | The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches |
| title_sort | heterogeneity of neutrophil recruitment in the tumor microenvironment and the formation of premetastatic niches |
| url | http://dx.doi.org/10.1155/2021/6687474 |
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