Plasmacytoid Dendritic Cells: From Heart to Vessels
Cardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immune-based pathologies. Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/430318 |
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| _version_ | 1832560797763502080 |
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| author | Rosalinda Sorrentino Silvana Morello Aldo Pinto |
| author_facet | Rosalinda Sorrentino Silvana Morello Aldo Pinto |
| author_sort | Rosalinda Sorrentino |
| collection | DOAJ |
| description | Cardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immune-based pathologies.
Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via the recruitment of T regulatory cells that downmodulate proinflammatory responses.
pDCs populate the vessel wall layers during pathological conditions, such as atherosclerosis. It is thus clear that a better identification of pDCs activity in cardiovascular diseases can not only elucidate pathological mechanisms but also lead to new therapeutic approaches. |
| format | Article |
| id | doaj-art-33e105416b694db899e9b1c739e71dae |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-33e105416b694db899e9b1c739e71dae2025-02-03T01:26:37ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322010-01-01201010.1155/2010/430318430318Plasmacytoid Dendritic Cells: From Heart to VesselsRosalinda Sorrentino0Silvana Morello1Aldo Pinto2Pharmaceutical Science Department, University of Salerno, 84084 Fisciano, ItalyPharmaceutical Science Department, University of Salerno, 84084 Fisciano, ItalyPharmaceutical Science Department, University of Salerno, 84084 Fisciano, ItalyCardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immune-based pathologies. Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via the recruitment of T regulatory cells that downmodulate proinflammatory responses. pDCs populate the vessel wall layers during pathological conditions, such as atherosclerosis. It is thus clear that a better identification of pDCs activity in cardiovascular diseases can not only elucidate pathological mechanisms but also lead to new therapeutic approaches.http://dx.doi.org/10.1155/2010/430318 |
| spellingShingle | Rosalinda Sorrentino Silvana Morello Aldo Pinto Plasmacytoid Dendritic Cells: From Heart to Vessels International Journal of Vascular Medicine |
| title | Plasmacytoid Dendritic Cells: From Heart to Vessels |
| title_full | Plasmacytoid Dendritic Cells: From Heart to Vessels |
| title_fullStr | Plasmacytoid Dendritic Cells: From Heart to Vessels |
| title_full_unstemmed | Plasmacytoid Dendritic Cells: From Heart to Vessels |
| title_short | Plasmacytoid Dendritic Cells: From Heart to Vessels |
| title_sort | plasmacytoid dendritic cells from heart to vessels |
| url | http://dx.doi.org/10.1155/2010/430318 |
| work_keys_str_mv | AT rosalindasorrentino plasmacytoiddendriticcellsfromhearttovessels AT silvanamorello plasmacytoiddendriticcellsfromhearttovessels AT aldopinto plasmacytoiddendriticcellsfromhearttovessels |