Research Progress on Tumor Treatment Strategies Targeting TGF-β
The TGF-β signaling pathway affects various biological processes of cancers, including proliferation, invasion, metastasis, angiogenesis, and immune escape. Currently, multiple drugs targeting this pathway are in clinical trial stage, which involve three aspects of TGF-β, namely, production, activat...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2025-01-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0735 |
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| _version_ | 1832590803136937984 |
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| author | Jian ZHANG Binyue LYU Xiao ZHAO |
| author_facet | Jian ZHANG Binyue LYU Xiao ZHAO |
| author_sort | Jian ZHANG |
| collection | DOAJ |
| description | The TGF-β signaling pathway affects various biological processes of cancers, including proliferation, invasion, metastasis, angiogenesis, and immune escape. Currently, multiple drugs targeting this pathway are in clinical trial stage, which involve three aspects of TGF-β, namely, production, activation, and signal transduction. Based on current evidence, the therapeutic effect of TGF-β monotherapy on advanced solid tumors is limited. Combination therapies that show promising results include combination with PD-1 antibodies, and combination with radiotherapy and chemotherapy. New combination therapies, such as CAR-T therapy modified with TGF-βRII, are also emerging in clinical research. This article systematically reviews the therapeutic strategies targeting TGF-β to provide research basis and ideas for the development of drugs targeting the TGF-β pathway. |
| format | Article |
| id | doaj-art-33e0ee1b3dab4e51bdde9bb204b5e91a |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-33e0ee1b3dab4e51bdde9bb204b5e91a2025-01-23T07:44:48ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-01-01521747810.3971/j.issn.1000-8578.2025.24.073520240735Research Progress on Tumor Treatment Strategies Targeting TGF-βJian ZHANG0Binyue LYU1Xiao ZHAO2Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Infectious Disease, The First Hospital of Tsinghua University, Beijing 100020, ChinaDepartment of Oncology, General Hospital of Chinese PLA, Fifth Medical Center, Beijing 100080, ChinaThe TGF-β signaling pathway affects various biological processes of cancers, including proliferation, invasion, metastasis, angiogenesis, and immune escape. Currently, multiple drugs targeting this pathway are in clinical trial stage, which involve three aspects of TGF-β, namely, production, activation, and signal transduction. Based on current evidence, the therapeutic effect of TGF-β monotherapy on advanced solid tumors is limited. Combination therapies that show promising results include combination with PD-1 antibodies, and combination with radiotherapy and chemotherapy. New combination therapies, such as CAR-T therapy modified with TGF-βRII, are also emerging in clinical research. This article systematically reviews the therapeutic strategies targeting TGF-β to provide research basis and ideas for the development of drugs targeting the TGF-β pathway.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0735tgf-βcancertherapeutic strategiestumor immune environment |
| spellingShingle | Jian ZHANG Binyue LYU Xiao ZHAO Research Progress on Tumor Treatment Strategies Targeting TGF-β Zhongliu Fangzhi Yanjiu tgf-β cancer therapeutic strategies tumor immune environment |
| title | Research Progress on Tumor Treatment Strategies Targeting TGF-β |
| title_full | Research Progress on Tumor Treatment Strategies Targeting TGF-β |
| title_fullStr | Research Progress on Tumor Treatment Strategies Targeting TGF-β |
| title_full_unstemmed | Research Progress on Tumor Treatment Strategies Targeting TGF-β |
| title_short | Research Progress on Tumor Treatment Strategies Targeting TGF-β |
| title_sort | research progress on tumor treatment strategies targeting tgf β |
| topic | tgf-β cancer therapeutic strategies tumor immune environment |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0735 |
| work_keys_str_mv | AT jianzhang researchprogressontumortreatmentstrategiestargetingtgfb AT binyuelyu researchprogressontumortreatmentstrategiestargetingtgfb AT xiaozhao researchprogressontumortreatmentstrategiestargetingtgfb |