Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis
ABSTRACT Background Immune‐mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and persistent inflammation. Rheumatoid arthritis (RA), spondyloarthritis (SpA), and ulcerative colitis (UC) exemplify prominent IMIDs, each presenting u...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70080 |
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| author | Ada Corrado Ilaria Guadagni Giovanna Picarelli Angela Variola |
| author_facet | Ada Corrado Ilaria Guadagni Giovanna Picarelli Angela Variola |
| author_sort | Ada Corrado |
| collection | DOAJ |
| description | ABSTRACT Background Immune‐mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and persistent inflammation. Rheumatoid arthritis (RA), spondyloarthritis (SpA), and ulcerative colitis (UC) exemplify prominent IMIDs, each presenting unique challenges for their management, that impact patient's quality of life (QoL). Obesity, marked by persistent low‐grade inflammation, influences the progression, response to treatment, and clinical management of patients with RA, SpA, and UC. Besides, the emerging role of sarcopenic obesity, a special subtype of obesity with malnutrition, should be considered in the definition of the appropriated therapeutic interventions. Methods This narrative literature review summarizes recent evidence on the interplay between obesity‐induced inflammation and IMIDs. Results Obesity contributes to elevated levels of proinflammatory cytokines, influencing the inflammatory pathways common to IMIDs. White adipose tissue, acting as an endocrine organ, produces cytokines like TNF‐α and IL‐6, fueling chronic inflammation. The dysregulation of adipokines, such as leptin and adiponectin, further complicates this interplay, impacting immune responses and metabolic processes. Conclusions Understanding the cross‐talk between inflammatory pathways in obesity and IMIDs can provide insight into potential targets for intervention. This includes lifestyle modifications aimed to regulate weight gain, paving the way for comprehensive strategies to manage IMIDs in the context of obesity. |
| format | Article |
| id | doaj-art-33dff87af0eb4606a265467b9d51405f |
| institution | Kabale University |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-33dff87af0eb4606a265467b9d51405f2025-02-06T07:50:38ZengWileyImmunity, Inflammation and Disease2050-45272025-01-01131n/an/a10.1002/iid3.70080Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative ColitisAda Corrado0Ilaria Guadagni1Giovanna Picarelli2Angela Variola3Department of Medical and Surgical Sciences, Rheumatology Clinic University of Foggia Foggia ItalyMedical Department Pfizer Italy Rome ItalyMedical Department Pfizer Italy Rome ItalyIBD Unit IRCCS Sacro Cuore Don Calabria Negrar ItalyABSTRACT Background Immune‐mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and persistent inflammation. Rheumatoid arthritis (RA), spondyloarthritis (SpA), and ulcerative colitis (UC) exemplify prominent IMIDs, each presenting unique challenges for their management, that impact patient's quality of life (QoL). Obesity, marked by persistent low‐grade inflammation, influences the progression, response to treatment, and clinical management of patients with RA, SpA, and UC. Besides, the emerging role of sarcopenic obesity, a special subtype of obesity with malnutrition, should be considered in the definition of the appropriated therapeutic interventions. Methods This narrative literature review summarizes recent evidence on the interplay between obesity‐induced inflammation and IMIDs. Results Obesity contributes to elevated levels of proinflammatory cytokines, influencing the inflammatory pathways common to IMIDs. White adipose tissue, acting as an endocrine organ, produces cytokines like TNF‐α and IL‐6, fueling chronic inflammation. The dysregulation of adipokines, such as leptin and adiponectin, further complicates this interplay, impacting immune responses and metabolic processes. Conclusions Understanding the cross‐talk between inflammatory pathways in obesity and IMIDs can provide insight into potential targets for intervention. This includes lifestyle modifications aimed to regulate weight gain, paving the way for comprehensive strategies to manage IMIDs in the context of obesity.https://doi.org/10.1002/iid3.70080chronic inflammationimmune‐mediated inflammatory diseases (IMIDs)inflammatory bowel disease (IBD)obesityrheumatoid arthritis (RA)spondyloarthritis (SpA) |
| spellingShingle | Ada Corrado Ilaria Guadagni Giovanna Picarelli Angela Variola Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis Immunity, Inflammation and Disease chronic inflammation immune‐mediated inflammatory diseases (IMIDs) inflammatory bowel disease (IBD) obesity rheumatoid arthritis (RA) spondyloarthritis (SpA) |
| title | Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis |
| title_full | Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis |
| title_fullStr | Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis |
| title_full_unstemmed | Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis |
| title_short | Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis |
| title_sort | obesity and chronic inflammation implications for rheumatoid arthritis spondyloarthritis and ulcerative colitis |
| topic | chronic inflammation immune‐mediated inflammatory diseases (IMIDs) inflammatory bowel disease (IBD) obesity rheumatoid arthritis (RA) spondyloarthritis (SpA) |
| url | https://doi.org/10.1002/iid3.70080 |
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