Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease
Microglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as Alzheimer’s disease (AD). Microglia seemingly demonstrate two contradictory ph...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8836173 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550544048128000 |
|---|---|
| author | Long Li Le Li Jiayong Zhang Sheng Huang Weilin Liu Zhifu Wang Shengxiang Liang Jing Tao Lidian Chen |
| author_facet | Long Li Le Li Jiayong Zhang Sheng Huang Weilin Liu Zhifu Wang Shengxiang Liang Jing Tao Lidian Chen |
| author_sort | Long Li |
| collection | DOAJ |
| description | Microglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as Alzheimer’s disease (AD). Microglia seemingly demonstrate two contradictory phenotypes in response to different microenvironmental cues, the M1 phenotype and the M2 phenotype, which are detrimental and beneficial to pathogenesis, respectively. Inhibiting the M1 phenotype with simultaneous promoting the M2 phenotype has been suggested as a potential therapeutic approach for cure AD. In this study, we demonstrated that electroacupuncture at the Shenting and Baihui acupoints for 16 weeks could improve learning and memory in the Morris water maze test and reduce amyloid β-protein in the parietal association cortex and entorhinal cortex in mice with mild and moderate AD. Besides, electroacupuncture at the Shenting and Baihui acupoints not only suppressed M1 marker (iNOS/IL-1β) expression but also increased the M2 marker (CD206/Arg1) expression in those regions. We propose that electroacupuncture at the Shenting and Baihui acupoints could regulate microglial polarization and decrease Aβ plaques to improve learning and memory in mild AD mice. |
| format | Article |
| id | doaj-art-33cce9428d7d480483e769e3dfe84e10 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-33cce9428d7d480483e769e3dfe84e102025-02-03T06:06:29ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88361738836173Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s DiseaseLong Li0Le Li1Jiayong Zhang2Sheng Huang3Weilin Liu4Zhifu Wang5Shengxiang Liang6Jing Tao7Lidian Chen8College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaFujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian 350122, ChinaFujian Key Laboratory of Rehabilitation Technology, Fuzhou, Fujian 350122, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaNational-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaMicroglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as Alzheimer’s disease (AD). Microglia seemingly demonstrate two contradictory phenotypes in response to different microenvironmental cues, the M1 phenotype and the M2 phenotype, which are detrimental and beneficial to pathogenesis, respectively. Inhibiting the M1 phenotype with simultaneous promoting the M2 phenotype has been suggested as a potential therapeutic approach for cure AD. In this study, we demonstrated that electroacupuncture at the Shenting and Baihui acupoints for 16 weeks could improve learning and memory in the Morris water maze test and reduce amyloid β-protein in the parietal association cortex and entorhinal cortex in mice with mild and moderate AD. Besides, electroacupuncture at the Shenting and Baihui acupoints not only suppressed M1 marker (iNOS/IL-1β) expression but also increased the M2 marker (CD206/Arg1) expression in those regions. We propose that electroacupuncture at the Shenting and Baihui acupoints could regulate microglial polarization and decrease Aβ plaques to improve learning and memory in mild AD mice.http://dx.doi.org/10.1155/2020/8836173 |
| spellingShingle | Long Li Le Li Jiayong Zhang Sheng Huang Weilin Liu Zhifu Wang Shengxiang Liang Jing Tao Lidian Chen Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease Neural Plasticity |
| title | Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease |
| title_full | Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease |
| title_fullStr | Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease |
| title_full_unstemmed | Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease |
| title_short | Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease |
| title_sort | disease stage associated alterations in learning and memory through the electroacupuncture modulation of the cortical microglial m1 m2 polarization in mice with alzheimer s disease |
| url | http://dx.doi.org/10.1155/2020/8836173 |
| work_keys_str_mv | AT longli diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease AT leli diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease AT jiayongzhang diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease AT shenghuang diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease AT weilinliu diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease AT zhifuwang diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease AT shengxiangliang diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease AT jingtao diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease AT lidianchen diseasestageassociatedalterationsinlearningandmemorythroughtheelectroacupuncturemodulationofthecorticalmicroglialm1m2polarizationinmicewithalzheimersdisease |