Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy
Introduction. About 600 new cases of malignant neoplasms of the paranasal sinuses and nasal cavity are detected annually in Russia. To date, there are no randomized trials to determine the optimal treatment algorithm for this group of patients. Data on the use of induction chemotherapy in squamous c...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2023-03-01
|
| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/838 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849401750744727552 |
|---|---|
| author | T. I. Dеshkina L. V. Bolotina A. R. Gevorkov A. V. Boyko A. L. Kornietskaya A. P. Polyakov P. V. Golubev R. S. Sydykova A. A. Fedenko |
| author_facet | T. I. Dеshkina L. V. Bolotina A. R. Gevorkov A. V. Boyko A. L. Kornietskaya A. P. Polyakov P. V. Golubev R. S. Sydykova A. A. Fedenko |
| author_sort | T. I. Dеshkina |
| collection | DOAJ |
| description | Introduction. About 600 new cases of malignant neoplasms of the paranasal sinuses and nasal cavity are detected annually in Russia. To date, there are no randomized trials to determine the optimal treatment algorithm for this group of patients. Data on the use of induction chemotherapy in squamous cell carcinoma of sino-nasal tract are limited to a small series of clinical observations and, often, are retrospective in nature.Aim. Evaluation of the effectiveness of induction chemotherapy in patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity.Materials and methods. Since 2012, 22 patients with locally advanced cancer of the paranasal sinuses and nasal cavity have been treated in our center, who underwent 3-component induction chemotherapy according to the TPF protocol. Evaluation of the effectiveness of treatment was carried out according to the criteria of Response evaluation criteria in solid tumors 1.1 (RECIST 1.1). Patients with a decrease in the tumor size by 30 % or more, were followed by radiation therapy in doses of 66–70 Gy. Patients with a residual tumor underwent surgery after the end of chemoradiotherapy.Results. In 21 patients available for analysis, overall response rate after induction chemotherapy was 71 %: complete response was registered in 3 (14 %) patients, partial response in 12 (57 %), stable disease in 4 (19 %). Progression disease after 3 courses of induction chemotherapy was detected in 2 (10 %) patients.Conclusions. Thus, induction chemotherapy in patients with squamous cell carcinoma of sino-nasal tractseems to be a promising direction for investigation, that can significantly improve the long-term results of treatment of this category of patients and help to avoid of disabling surgery in some of them. |
| format | Article |
| id | doaj-art-33c5fa7fbba3464c9dc8c5b10028eaff |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-33c5fa7fbba3464c9dc8c5b10028eaff2025-08-20T03:37:42ZrusABV-pressОпухоли головы и шеи2222-14682411-46342023-03-01124101610.17650/2222-1468-2022-12-4-10-16518Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapyT. I. Dеshkina0L. V. Bolotina1A. R. Gevorkov2A. V. Boyko3A. L. Kornietskaya4A. P. Polyakov5P. V. Golubev6R. S. Sydykova7A. A. Fedenko8P.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaP.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaP.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaP.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaP.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaP.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaP.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaP.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaP.A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaIntroduction. About 600 new cases of malignant neoplasms of the paranasal sinuses and nasal cavity are detected annually in Russia. To date, there are no randomized trials to determine the optimal treatment algorithm for this group of patients. Data on the use of induction chemotherapy in squamous cell carcinoma of sino-nasal tract are limited to a small series of clinical observations and, often, are retrospective in nature.Aim. Evaluation of the effectiveness of induction chemotherapy in patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity.Materials and methods. Since 2012, 22 patients with locally advanced cancer of the paranasal sinuses and nasal cavity have been treated in our center, who underwent 3-component induction chemotherapy according to the TPF protocol. Evaluation of the effectiveness of treatment was carried out according to the criteria of Response evaluation criteria in solid tumors 1.1 (RECIST 1.1). Patients with a decrease in the tumor size by 30 % or more, were followed by radiation therapy in doses of 66–70 Gy. Patients with a residual tumor underwent surgery after the end of chemoradiotherapy.Results. In 21 patients available for analysis, overall response rate after induction chemotherapy was 71 %: complete response was registered in 3 (14 %) patients, partial response in 12 (57 %), stable disease in 4 (19 %). Progression disease after 3 courses of induction chemotherapy was detected in 2 (10 %) patients.Conclusions. Thus, induction chemotherapy in patients with squamous cell carcinoma of sino-nasal tractseems to be a promising direction for investigation, that can significantly improve the long-term results of treatment of this category of patients and help to avoid of disabling surgery in some of them.https://ogsh.abvpress.ru/jour/article/view/838squamous cell carcinomainduction chemotherapycancer of the paranasal sinuses and nasal cavity |
| spellingShingle | T. I. Dеshkina L. V. Bolotina A. R. Gevorkov A. V. Boyko A. L. Kornietskaya A. P. Polyakov P. V. Golubev R. S. Sydykova A. A. Fedenko Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy Опухоли головы и шеи squamous cell carcinoma induction chemotherapy cancer of the paranasal sinuses and nasal cavity |
| title | Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy |
| title_full | Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy |
| title_fullStr | Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy |
| title_full_unstemmed | Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy |
| title_short | Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy |
| title_sort | results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy |
| topic | squamous cell carcinoma induction chemotherapy cancer of the paranasal sinuses and nasal cavity |
| url | https://ogsh.abvpress.ru/jour/article/view/838 |
| work_keys_str_mv | AT tideshkina resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy AT lvbolotina resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy AT argevorkov resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy AT avboyko resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy AT alkornietskaya resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy AT appolyakov resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy AT pvgolubev resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy AT rssydykova resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy AT aafedenko resultsofcomplextreatmentofpatientswithlocallyadvancedsquamouscellcarcinomaoftheparanasalsinusesandnasalcavityusinginductionchemotherapy |