Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure Glue
Purpose. This study aims to measure burst pressures in 3 mm clear corneal incisions sealed with ReSure, a biodegradable hydrogel sealant, and to compare it to traditional 10-0 nylon sutures and unsealed controls. Design. An ex vivo animal study. Methods. 3 mm clear corneal incisions were performed i...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2021/6691489 |
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| author | Ahmed E. M. Shehata Siva P. Kambhampati Jiangxia Wang Uri S. Soiberman |
| author_facet | Ahmed E. M. Shehata Siva P. Kambhampati Jiangxia Wang Uri S. Soiberman |
| author_sort | Ahmed E. M. Shehata |
| collection | DOAJ |
| description | Purpose. This study aims to measure burst pressures in 3 mm clear corneal incisions sealed with ReSure, a biodegradable hydrogel sealant, and to compare it to traditional 10-0 nylon sutures and unsealed controls. Design. An ex vivo animal study. Methods. 3 mm clear corneal incisions were performed in rabbit eyes (ex vivo). The burst pressure was determined, and then, the incisions were sealed with either ReSure glue or a single 10-0 nylon suture. Burst pressure measurements were repeated. Results. Fourteen eyes were included. The median burst pressure in the suture-control group (7 eyes) prior to suture application was 7 mmHg (range: 0–45); the median burst pressure in the 7 glue-controls was 36 mmHg (range: 5–61, p = 0.08 for the comparison of the two control groups). The median burst pressure in the glue group was 93 mmHg (range: 39–129, p = 0.043 when compared to glue-control). The median burst pressure in the suture group was 158 mmHg (range: 70–180, p = 0.018 when compared to suture-control). There was no statistically significant difference in burst pressure values between the glue and suture groups (p = 0.08). Conclusion. In this study, ReSure glue applied to 3 mm clear corneal incisions provided sufficient resistance to elevated intraocular pressure when compared to controls. The results of this study suggest that ReSure glue may be comparable to a single 10-0 nylon suture in resisting fluid egress during the early postoperative period. |
| format | Article |
| id | doaj-art-33be0a6cab0b4125979bddcf369ae340 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-33be0a6cab0b4125979bddcf369ae3402025-02-03T06:05:45ZengWileyJournal of Ophthalmology2090-004X2090-00582021-01-01202110.1155/2021/66914896691489Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure GlueAhmed E. M. Shehata0Siva P. Kambhampati1Jiangxia Wang2Uri S. Soiberman3Cornea Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USACenter for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USACornea Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USAPurpose. This study aims to measure burst pressures in 3 mm clear corneal incisions sealed with ReSure, a biodegradable hydrogel sealant, and to compare it to traditional 10-0 nylon sutures and unsealed controls. Design. An ex vivo animal study. Methods. 3 mm clear corneal incisions were performed in rabbit eyes (ex vivo). The burst pressure was determined, and then, the incisions were sealed with either ReSure glue or a single 10-0 nylon suture. Burst pressure measurements were repeated. Results. Fourteen eyes were included. The median burst pressure in the suture-control group (7 eyes) prior to suture application was 7 mmHg (range: 0–45); the median burst pressure in the 7 glue-controls was 36 mmHg (range: 5–61, p = 0.08 for the comparison of the two control groups). The median burst pressure in the glue group was 93 mmHg (range: 39–129, p = 0.043 when compared to glue-control). The median burst pressure in the suture group was 158 mmHg (range: 70–180, p = 0.018 when compared to suture-control). There was no statistically significant difference in burst pressure values between the glue and suture groups (p = 0.08). Conclusion. In this study, ReSure glue applied to 3 mm clear corneal incisions provided sufficient resistance to elevated intraocular pressure when compared to controls. The results of this study suggest that ReSure glue may be comparable to a single 10-0 nylon suture in resisting fluid egress during the early postoperative period.http://dx.doi.org/10.1155/2021/6691489 |
| spellingShingle | Ahmed E. M. Shehata Siva P. Kambhampati Jiangxia Wang Uri S. Soiberman Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure Glue Journal of Ophthalmology |
| title | Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure Glue |
| title_full | Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure Glue |
| title_fullStr | Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure Glue |
| title_full_unstemmed | Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure Glue |
| title_short | Burst Pressures in Eyes with Clear Corneal Incisions Treated with ReSure Glue |
| title_sort | burst pressures in eyes with clear corneal incisions treated with resure glue |
| url | http://dx.doi.org/10.1155/2021/6691489 |
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